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Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly
Open accessAbstract
OBJECTIVE: To better understand cross-sectional relationships between CSF and PET measures of tau pathology, we compared regional and global measures of (18)F-T807 (AV-1451) PET to CSF protein levels of total tau (t-tau), phosphorylated tau (p-tau), and β-amyloid 1-42 (Aβ42). METHODS: T-tau, p-tau, and Aβ42 levels were assessed using INNOTEST xMAP immunoassays. Linear regression was used to compare regional and global measures of (18)F-T807 standardized uptake value ratios (SUVR) to CSF protein levels using data from 31 cognitively unimpaired elderly participants in the Harvard Aging Brain study. RESULTS: After controlling for sex and age, total cortical (18)F-T807 binding was significantly correlated with p-tau (partial r = 0.48; p < 0.01) and at trend level with t-tau (partial r = 0.30; p = 0.12). Regional (18)F-T807 measures were more strongly correlated with CSF protein levels than the global measure, with both t-tau and p-tau significantly correlated with (18)F-T807 SUVR in entorhinal, parahippocampal, and inferior temporal cortical regions (partial r = 0.53-0.73). Peak correlations between CSF and PET measures of tau were similar to those between CSF and PET measures of amyloid burden. Finally, we observed significantly higher temporal T807 SUVR in individuals with high amyloid burden. CONCLUSIONS: These data support the link between (18)F-T807 PET and CSF measures of tau pathology. In these cognitively normal individuals with (18)F-T807 binding largely restricted to the temporal lobe, (18)F-T807 SUVR in temporal regions appeared more reflective of CSF t-tau and p-tau than a total cortical measure.
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“In the limited data currently available, tau PET ligand binding is linearly correlated with elevated CSF P-tau [82,83,115]; however, the correlation is imperfect.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [83]
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“In the limited data currently available, tau PET ligand binding is linearly correlated with elevated CSF P-tau [82,83,115]; however, the correlation is imperfect.”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [83]
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“Studies comparing CSF tau biomarkers with Tau PET have found that they are only moderately correlated, with the strongest correlations in symptomatic stages of AD, and no or weak correlations in cognitively unimpaired (CU) individuals (12–16).”
From Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive tau PET in Alzheimer's disease (2020) · cites this paper as [13]
In the citing paper
“These previous studies suggest that CSF tau biomarkers and Tau PET reflect different aspects of tau pathology and may become abnormal at different stages of the disease.”
From Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive tau PET in Alzheimer's disease (2020) · cites this paper as [13]
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References 28 · Cited by 106
Research works printed but not linked: 1
- Weschler D. WMS-R: Weschler Memory Scale-Revised Manual. New York: Psychological Corporation/HBJ; 1987.
Metadata
- Authors
- Chhatwal, J. P., Schultz, A. P., Marshall, G. A., Boot, B., Gomez-Isla, T., Dumurgier, J., LaPoint, M., Scherzer, C., Roe, A. D., Hyman, B. T., Sperling, R. A., & Johnson, K. A.
- Affiliations
- Brigham and Women's Hospital (US)
- From Harvard Medical School (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., C.S., B.T.H., R.A.S., K.A.J.); Massachusetts General Hospital (J.P.C., A.P.S., G.A.M., B.B., T.G.-I., J.D., M.L., A.D.R., B.T.H., R.A.S., K.A.J.), Boston; Martinos Center for Biomedical Imaging (J.P.C., A.P.S., M.L., R.A.S., K.A.J.), Charlestown; Brigham and Women's Hospital (G.A.M., B.B., C.S., R.A.S., K.A.J.), Boston; Biogen (B.B.), Cambridge, MA; Lariboisiere Hospital Memory Center (J.D.), APHP, University Paris 7 Denis Diderot,...
- ORCID
- Venue
- Neurology
- Published
- 2016-08-30
- Volume
- 87
- Issue
- 9
- Pages
- 920-926
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC5035159
- OpenAlex
- W2488836793
- Cited by
- 106
- References
- 28
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 4 · 2022: 9 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 18 · 2017: 15 · 2016: 4
- FWCI
- 15.39
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5u01ag024904-10, UL1TR000170, UL1TR001102)
- National Institute on Aging (U01-AG-024904, K23AG049087, K24AG035007, R01AG046396, U19AG010483, P01AG036694)
- National Institute of Neurological Disorders and Stroke (U01NS082157)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- tau PET, cerebrospinal fluid tau, phosphorylated tau, total tau, amyloid PET, amyloid-beta 42, temporal lobe, entorhinal cortex, parahippocampal cortex, inferior temporal cortex, Alzheimer's disease biomarkers
- MeSH terms
- Aged, Aged, 80 and over, Brain, Carbolines, Cross-Sectional Studies, Female, Humans, Magnetic Resonance Imaging, Male, Mental Status Schedule, Phosphorylation, Temporal Lobe, Geriatric Assessment, Amyloid beta-Peptides, tau Proteins, Positron-Emission Tomography, Apolipoprotein E4
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