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Cited by 140Nutritional Studies and DietDementia and Cognitive Impairment ResearchFatty Acid Research and Health

The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.

Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort

Open access
Luciano, Michelle, Corley, Janie, Cox, Simon R., Valdés Hernández, Maria C., Craig, Leone C.A., Dickie, David Alexander, Karama, Sherif, McNeill, Geraldine M., Bastin, Mark E., Wardlaw, Joanna M., Deary, Ian J.·2017·Neurology
DOI 10.1212/wnl.0000000000003559PMC PMC5278943
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Abstract

OBJECTIVE: To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73-76 years). METHODS: We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection. RESULTS: In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance, p < 0.05). This effect was half the size of the largest covariate effect (i.e., age). Cross-sectional associations between MeDi and baseline MRI measures in 562 participants were not significant. Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume. CONCLUSIONS: Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.

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Figure Stages of data collection and sample size of dietary and MRI data in the Lothian Birth Cohort of 1936
Figure Stages of data collection and sample size of dietary and MRI data in the Lothian Birth Cohort of 1936CC BY · PubMed Central

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  1. Nelson HE, Willison JR. National Adult Reading Test (NART) Test Manual (Part II). Windsor, UK: NFER-Nelson; 1991.

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Metadata

Authors
Luciano, M., Corley, J., Cox, S. R., Valdés Hernández, M. C., Craig, L. C. A., Dickie, D. A., Karama, S., McNeill, G. M., Bastin, M. E., Wardlaw, J. M., & Deary, I. J.
Affiliations
  • From the Centre for Cognitive Ageing and Cognitive Epidemiology (M.L., J.C., S.R.C., I.J.D.), Department of Psychology (M.L., J.C., S.R.C., I.J.D.), Brain Research Imaging Centre (M.C.V.H., D.A.D., M.E.B., J.M.W.), Centre for Clinical Brain Sciences (M.C.V.H., D.A.D., M.E.B., J.M.W.), and Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences (S.R.C., M.C.V.H., D.A.D., M.E.B., J.M.W.), University of Edinburgh; Rowett Institute of...
  • Montreal Neurological Institute and Hospital (CA)
ORCID
Venue
Neurology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-01-31
Volume
88
Issue
5
Pages
449-455
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
DOI
10.1212/wnl.0000000000003559
PMC
PMC5278943
OpenAlex
W2569405552
Cited by
140
References
29
Citations by year
2026: 10 · 2025: 5 · 2024: 11 · 2023: 27 · 2022: 13 · 2021: 15 · 2020: 14 · 2019: 17 · 2018: 22 · 2017: 6
FWCI
15.09
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Neurology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
  • Aberdeen University Research Archive (Aberdeen University) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
Funders
  • Medical Research Council (MR/K026992/1, MR/M013111/1, MR/N003403/1, MR/N027558/1)
  • Biotechnology and Biological Sciences Research Council
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Keywords
dietary adherence, brain atrophy, total brain volume, gray matter volume, cortical thickness, older adults, longitudinal brain MRI, fish consumption, meat consumption
MeSH terms
Aged, Aging, Brain, Cross-Sectional Studies, Female, Humans, Longitudinal Studies, Magnetic Resonance Imaging, Male, Organ Size, Prospective Studies, Surveys and Questionnaires, Regression Analysis, Scotland, Sex Characteristics, Diet, Mediterranean, Gray Matter

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