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Late-life blood pressure association with cerebrovascular and Alzheimer disease pathology
Open accessAbstract
Objective To examine associations of average and change in late-life blood pressure (BP) with cerebrovascular and Alzheimer disease (AD) neuropathology in a large group of decedents followed longitudinally in vivo. Methods This clinical-pathologic study was derived from prospective, community-based cohort studies of aging with similar design and data collection. Measurements of systolic BP (SBP) and diastolic BP (DBP) were obtained annually (mean follow-up 8 years, SD = 4.8). Postmortem neuropathologic evaluations documented diseases of aging. Using regression analyses, we examined associations of average and decline in late-life SBP, and separately in DBP, with neuropathology. Results In 1,288 persons (mean age at death = 88.6 years; 65% women), the mean standardized person-specific SBP across the study was 134 (SD = 13) and DBP was 71 (SD = 8) mm Hg. The odds of brain infarcts were increased for participants with a higher mean SBP. Specifically, a person with a 1 SD SBP above the mean (147 vs 134 mm Hg) would have a 46% increased odds of having one or more infarcts, and an increased odds of gross infarct (46%) and microinfarct (36%). Furthermore, a more rapidly declining SBP slope over time increased the odds of one or more infarcts. Mean DBP, not slope, was related to brain infarcts. AD pathology analyses showed an association of a higher mean SBP with higher number of tangles (p = 0.038) but not plaques or other pathology (all p > 0.06). Changes in BP were not significantly related to AD pathology. Conclusions Higher average late-life SBP and DBP, and independently a faster decline in SBP, are associated with increasing number of brain infarcts, including gross and microinfarcts. We found some evidence for a relation of SBP with AD, specifically tangles. Both average and decline in BP are related to brain disease.
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“while vascular risk factors like higher blood pressure levels have been found associated with cerebral vessel disease including arteriolosclerosis [28,3]”
From Sex differences in Alzheimer’s disease and common neuropathologies of aging (2018) · cites this paper as [3]
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“A recent clinical-pathologic study showed that higher systolic blood pressure (147 vs. 134 mm Hg) increased the odds of having one or more brain infarcts by 46%, a gross infarct by 46%, and microinfarcts by 36%43.”
From Mechanisms and treatment of late-life depression (2019) · cites this paper as [43]
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Cites
Chobanian, A. V., Bakris, G. L., Black, H. R., Cushman, W. C., Green, L. A., Izzo, J. L., Jones, D. W., Materson, B. J., Oparil, S., Wright, J. T., et al. (2003) · Hypertension · doi:10.1161/01.hyp.0000107251.49515.c2 · Cited by 13,271
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
Schneider, J. A., Arvanitakis, Z., Bang, W., & Bennett, D. A. (2007) · Neurology · doi:10.1212/01.wnl.0000271090.28148.24 · Cited by 1,992
Self-citation15-year longitudinal study of blood pressure and dementia
Skoog, I., Nilsson, L., Persson, G., Lernfelt, B., Landahl, S., Palmertz, B., Andreasson, L.-A., Odén, A., & Svanborg, A. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90608-x · Cited by 1,726
Overview and Findings from the Rush Memory and Aging Project
Bennett, D. A., Schneider, J. A., Buchman, A. S., Barnes, L. L., Boyle, P. A., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322663 · Cited by 849
Self-citationOverview and Findings from the Religious Orders Study
Bennett, D. A., Schneider, J. A., Arvanitakis, Z., & Wilson, R. S. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322573 · Cited by 656
Self-citationMechanisms and treatment of late-life depression
Alexopoulos, G. S. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0514-6 · Cited by 592
Petrovitch, H., White, L. R., Izmirilian, G., Ross, G. W., Havlik, R. J., Markesbery, W., Nelson, J., Davis, D. G., Hardman, J., Foley, D. J., et al. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00106-8 · Cited by 468
Microinfarct Pathology, Dementia, and Cognitive Systems
Arvanitakis, Z., Leurgans, S. E., Barnes, L. L., Bennett, D. A., & Schneider, J. A. (2011) · Stroke · doi:10.1161/strokeaha.110.595082 · Cited by 404
Self-citationLow blood pressure and the risk of dementia in very old individuals
Verghese, J., Lipton, R. B., Hall, C. B., Kuslansky, G., & Katz, M. (2003) · Neurology · doi:10.1212/01.wnl.0000098934.18300.be · Cited by 316
Maillard, P., Seshadri, S. S., Beiser, A., Himali, J. J., Au, R., Fletcher, E., Carmichael, O. T., Wolf, P. A., & DeCarli, C. S. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70241-7 · Cited by 312
Relation of cerebral infarctions to dementia and cognitive function in older persons
Schneider, J. A., Wilson, R. S., Cochran, E. J., Bienias, J. L., Arnold, S. E., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000055863.87435.b2 · Cited by 305
Self-citationBarnes, L. L., Shah, R. C., Aggarwal, N. T., Bennett, D. A., & Schneider, J. A. (2012) · Current Alzheimer Research · doi:10.2174/156720512801322627 · Cited by 305
Self-citationComponents of blood pressure and risk of atherothrombotic brain infarction: the Framingham study.
Kannel, W. B., Dawber, T. R., Sorlie, P. D., & Wolf, P. A. (1976) · Stroke · doi:10.1161/01.str.7.4.327 · Cited by 265
Change in Blood Pressure and Incident Dementia
Stewart, R. J., Xue, Q., Masaki, K., Petrovitch, H., Ross, G. W., White, L. R., & Launer, L. J. (2009) · Hypertension · doi:10.1161/hypertensionaha.109.128744 · Cited by 206
Long-term Blood Pressure Fluctuation and Cerebrovascular Disease in an Elderly Cohort
Brickman, A. M., Reitz, C., Luchsinger, J. A., Manly, J. J., Schupf, N., Muraskin, J., DeCarli, C. S., Brown, T. R., & Mayeux, R. P. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.70 · Cited by 205
The Relationship of Cerebral Vessel Pathology to Brain Microinfarcts
Arvanitakis, Z., Capuano, A. W., Leurgans, S. E., Buchman, A. S., Bennett, D. A. A., & Schneider, J. A. (2016) · Brain Pathology · doi:10.1111/bpa.12365 · Cited by 198
Self-citationBlood pressure levels and brain volume reduction
Beauchet, O., Celle, S., Roche, F., Bartha, R., Montero‐Odasso, M., Allali, G., & Annweiler, C. (2013) · Journal of Hypertension · doi:10.1097/hjh.0b013e32836184b5 · Cited by 182
Silent Cerebral Infarction in a Community-Based Autopsy Series in Japan
Shinkawa, A., Ueda, K., Kiyohara, Y., Kato, I., Sueishi, K., Tsuneyoshi, M., & Fujishima, M. (1995) · Stroke · doi:10.1161/01.str.26.3.380 · Cited by 160
Less Alzheimer disease neuropathology in medicated hypertensive than nonhypertensive persons
Hoffman, L. B., Schmeidler, J., Lesser, G. T., Beeri, M. S., Purohit, D. P., Grossman, H. T., & Haroutunian, V. (2009) · Neurology · doi:10.1212/01.wnl.0000345881.82856.d5 · Cited by 157
Wright, J. D., Hughes, J. P., Ostchega, Y., Yoon, S. S., & Nwankwo, T. (2011) · PubMed · Cited by 147
Li, G., Rhew, I. C., Shofer, J. B., Kukull, W. A., Breitner, J. C. S., Peskind, E. R., Bowen, J. D., McCormick, W. C., Teri, L. L., Crane, P. K., et al. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01233.x · Cited by 140
Nation, D. A., Edmonds, E. C., Bangen, K. J., Delano‐Wood, L., Scanlon, B. K., Han, S. D., Edland, S. D., Salmon, D. P., Galasko, D. R., & Bondi, M. W. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2014.4477 · Cited by 133
Diabetes and Function in Different Cognitive Systems in Older Individuals Without Dementia
Arvanitakis, Z., Wilson, R. S., Li, Y., Aggarwal, N. T., & Bennett, D. A. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-1901 · Cited by 129
Self-citationXu, H., Yang, R., Qi, X., Dintica, C. S., Song, R., Bennett, D. A., & Xu, W. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2019.2455 · Cited by 120
Self-citationSerum NfL (Neurofilament Light Chain) Levels and Incident Stroke in Adults With Diabetes Mellitus
Korley, F. K., Goldstick, J. E., Mastali, M., Eyk, J. E. V., Barsan, W. G., Meurer, W. J., Sussman, J. B., Falk, H. J., & Levine, D. A. (2019) · Stroke · doi:10.1161/strokeaha.119.024941 · Cited by 117
Low Diastolic Pressure and Risk of Dementia in Very Old People: A Longitudinal Study
Qiu, C., Winblad, B. G., & Fratiglioni, L. (2009) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000236913 · Cited by 74
Zheng, L., Vinters, H. V., Mack, W. J., Zarow, C., Ellis, W. G., & Chui, H. C. (2013) · Stroke · doi:10.1161/strokeaha.113.001945 · Cited by 70
Blood Pressure and Brain Injury in Older Adults: Findings from a Community‐Based Autopsy Study
Wang, L. Y., Larson, E. B., Sonnen, J. A., Shofer, J. B., McCormick, W. C., Bowen, J. D., Montine, T. J., & Li, G. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02493.x · Cited by 67
Diabetes, Hemoglobin A1C, and Regional Alzheimer Disease and Infarct Pathology
Pruzin, J. J., Schneider, J. A., Capuano, A. W., Leurgans, S. E., Barnes, L. L., Ahima, R. S., Arnold, S. E., Bennett, D. A., & Arvanitakis, Z. (2016) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0000000000000172 · Cited by 67
Self-citationShah, R. C., Wilson, R. S., Bienias, J. L., Arvanitakis, Z., Evans, D. A., & Bennett, D. A. (2005) · Neuroepidemiology · doi:10.1159/000089235 · Cited by 64
Self-citationBlood pressure in the very old
Heikinheimo, R., Haavisto, M., Kaarela, R. H., Kanto, A. J., Koivunen, M. J., & Rajala, S. (1990) · Journal of Hypertension · doi:10.1097/00004872-199004000-00010 · Cited by 58
A 2-process model for neuropathology of Alzheimer's disease
Mungas, D., Tractenberg, R., Schneider, J. A., Crane, P. K., & Bennett, D. A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.08.007 · Cited by 58
Self-citationBlood pressure trends and mortality
Poortvliet, R. K. E., de Ruijter, W., de Craen, A. J. M., Mooijaart, S. P., Westendorp, R. G. J., Assendelft, W. J., Gussekloo, J., & Blom, J. W. (2012) · Journal of Hypertension · doi:10.1097/hjh.0b013e32835aa351 · Cited by 55
Ruiz, A., Pesini, P., Espinosa, A., Pérez‐Grijalba, V., Valero, S., Sotolongo‐Grau, Ó., Alegret, M., Monleón, I., Lafuente, A., Buendía, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081334 · Cited by 44
Blood Pressure Circadian Variation, Cognition and Brain Imaging in 90+ Year-Olds
Paganini‐Hill, A., Bryant, N., Corrada, M. M., Greenia, D., Fletcher, E. M., Singh, B., Floriolli, D., Kawas, C. H., & Fisher, M. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00054 · Cited by 28
Association Between Microinfarcts and Blood Pressure Trajectories
Graff‐Radford, J., Raman, M. R., Rabinstein, A. A., Przybelski, S. A., Lesnick, T. G., Boeve, B. F., Murray, M. E., Dickson, D. W., Reichard, R. R., Parisi, J. E., et al. (2017) · JAMA Neurology · doi:10.1001/jamaneurol.2017.3392 · Cited by 19
Vascular Health is Associated with Amyloid-β in Cognitively Normal Older Adults
Liu, Y., Perdomo, S. J., Ward, J. L., Vidoni, E. D., Sisante, J. F., Kirkendoll, K., Burns, J. M., & Billinger, S. A. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181268 · Cited by 15
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Oveisgharan, S., Arvanitakis, Z., Yu, L., Farfel, J., Schneider, J. A., & Bennett, D. A. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1920-1 · Cited by 330
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Metadata
- Authors
- Arvanitakis, Z., Capuano, A. W., Lamar, M., Shah, R. C., Barnes, L. L., Bennett, D. A., & Schneider, J. A.
- Affiliations
- Rush University Medical Center (US)
- ORCID
- Venue
- Neurology
- Published
- 2018-08-07
- Volume
- 91
- Issue
- 6
- Pages
- e517-e525
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC6105052
- OpenAlex
- W2873977728
- Cited by
- 112
- References
- 38
- Citations by year
- 2026: 3 · 2025: 12 · 2024: 14 · 2023: 9 · 2022: 17 · 2021: 18 · 2020: 19 · 2019: 17 · 2018: 3
- FWCI
- 11.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG017917, RF1AG022018, R01AG015819, P30AG010161, R01AG040039, RF1AG015819, R01AG022018)
- National Institute of Neurological Disorders and Stroke (UH3NS100599, R01NS084965, UH2NS100599, UF1NS100599)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- systolic blood pressure, diastolic blood pressure, blood pressure reduction, Alzheimer disease pathology, cerebrovascular pathology, cerebral infarction, microinfarcts, neurofibrillary tangles, aging, postmortem neuropathology
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Alzheimer Disease, Blood Pressure, Brain, Cerebrovascular Disorders, Female, Follow-Up Studies, Humans, Hypertension, Male, Prospective Studies, Risk Factors, Cohort Studies
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