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Physical activity, common brain pathologies, and cognition in community-dwelling older adults
Open accessAbstract
OBJECTIVE: To examine the associations of physical activity, Alzheimer disease (AD), and other brain pathologies and cognition in older adults. METHODS: We studied 454 brain autopsies from decedents in a clinical-pathologic cohort study. Nineteen cognitive tests were summarized in a global cognitive score. Total daily physical activity summarized continuous multiday recordings of activity during everyday living in the community setting. A global motor ability score summarized 10 supervised motor performance tests. A series of regression analyses were used to examine associations of physical activity, AD, and other brain pathologies with global cognition proximate to death controlling for age, sex, education, and motor abilities. RESULTS: < 0.001) were independently associated with better cognition. These independent associations remained significant when terms for AD and other pathologies were added as well as in sensitivity analyses excluding cases with poor cognition or dementia. Adding interaction terms, the associations of total daily activity and motor abilities with cognition did not vary in individuals with and without dementia. The associations of AD and other pathologies with cognition did not vary with the levels of total daily activity or motor abilities. CONCLUSIONS: Physical activity in older adults may provide cognitive reserve to maintain function independent of the accumulation of diverse brain pathologies. Further studies are needed to identify the molecular mechanisms underlying this potential reserve and to ensure the causal effects of physical activity.
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“Physical activity is an example of a modifiable factor that reduces risk of cardiovascular disease and may also reduce risk of dementia.”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [125]
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“In contrast, physical activity appears to decrease risk. [119][120]0][121][122][123][124][125][126][127][128]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [121]
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References 47 · Cited by 108
Metadata
- Authors
- Buchman, A. S., Yu, L., Wilson, R. S., Lim, A., Dawe, R. J., Gaiteri, C., Leurgans, S. E., Schneider, J. A., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- ORCID
- Venue
- Neurology
- Published
- 2019-02-19
- Volume
- 92
- Issue
- 8
- Pages
- e811-e822
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC6396972
- OpenAlex
- W2910742973
- Cited by
- 108
- References
- 47
- Citations by year
- 2026: 12 · 2025: 12 · 2024: 18 · 2023: 17 · 2022: 11 · 2021: 23 · 2020: 10 · 2019: 5
- FWCI
- 9.74
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG017917, R01AG052488)
- National Institute of Neurological Disorders and Stroke (R01NS078009)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- physical activity, Alzheimer's disease, neuropathology, cognition, cognitive reserve, older adults, motor abilities, dementia, brain autopsy, community-dwelling older adults
- MeSH terms
- Aged, 80 and over, Alzheimer Disease, Autopsy, Brain, Cognition, DNA-Binding Proteins, Female, Humans, Male, Substantia Nigra, Exercise, Lewy Bodies, Independent Living
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