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Effect of aerobic exercise on cognition in younger adults: A randomized clinical trial
Open accessAbstract
OBJECTIVE: To determine efficacy of aerobic exercise for cognitive function in younger healthy adults. METHODS: In a randomized, parallel-group, observer-masked, community-based clinical trial, 132 cognitively normal individuals aged 20-67 with below median aerobic capacity were randomly assigned to one of two 6-month, 4-times-weekly conditions: aerobic exercise and stretching/toning. Efficacy measures included aerobic capacity; cognitive function in several domains (executive function, episodic memory, processing speed, language, and attention), everyday function, body mass index (BMI), and cortical thickness. RESULTS: = 0.0346). CONCLUSIONS: This randomized clinical trial demonstrates the efficacy of aerobic exercise for cognition in adults age 20-67. The effect of aerobic exercise on executive function was more pronounced as age increased, suggesting that it may mitigate age-related declines. Increased cortical thickness suggests that aerobic exercise contributes to brain health in individuals as young as age 20. CLINICALTRIALSGOV IDENTIFIER: NCT01179958. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that for adults age 20-67 with below median aerobic capacity, aerobic exercise significantly improves executive function but not other measures of cognitive function.
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“endurance training induces substantial structural brain changes (Erickson et al., 2011; Stern et al., 2019)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Stern et al., 2019
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“Furthermore, in response to endurance training, increases in VO2 max. (iv) mediate the improvement in cognitive functions in younger adults (Stern et al., 2019)”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Stern et al., 2019
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References 46 · Cited by 178
Research works printed but not linked: 2
- Mattis S. Mental Status examination for organic mental syndrome in the elderly patient. In: Bellak L, Karasu TB, eds. Geriatric Psychiatry. New York: Grune & Stratton;1976:77–121.
- Schmidt M. Rey Auditory and Verbal Learning Test. A Handbook. Los Angeles: Western Psychological Services; 1996.
Metadata
- Authors
- Stern, Y., MacKay-Brandt, A., Lee, S., McKinley, P., McIntyre, K., Razlighi, Q., Agarunov, E., Bartels, M., & Sloan, R. P.
- Affiliations
- Nathan Kline Institute for Psychiatric Research (US)
- From the Cognitive Neuroscience Division, Department of Neurology and Taub Institute (Y.S., A.M.-B., Q.R., E.A.), Department of Biostatistics (S.L.), and Department of Psychiatry, Division of Behavioral Medicine (P.M., K.M., R.P.S.), Columbia University, New York; Division of Clinical Research (A.M.-B.), Nathan Kline Institute for Psychiatric Research, Orangeburg; Division of Biostatistics (S.L.), New York State Psychiatric Institute; and Cardiopulmonary Rehabilitation and the Human Performance...
- ORCID
- Venue
- Neurology
- Published
- 2019-02-26
- Volume
- 92
- Issue
- 9
- Pages
- e905-e916
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC6404470
- OpenAlex
- W2914653050
- Cited by
- 178
- References
- 46
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 28 · 2023: 29 · 2022: 24 · 2021: 28 · 2020: 17 · 2019: 11
- FWCI
- 13.72
- Type
- journal article
- Language
- en
- Update notices
- correction (2019-07-22)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (K01AG051348, R01AG033546)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- aerobic exercise, cognitive function, executive function, episodic memory, processing speed, attention, cortical thickness, cardiorespiratory fitness, aging, brain health, body mass index, young adults
- MeSH terms
- Adult, Age Factors, Aged, Cerebral Cortex, Cognition, Humans, Magnetic Resonance Imaging, Middle Aged, Neuropsychological Tests, Organ Size, Oxygen Consumption, Exercise, Exercise Tolerance, Apolipoprotein E4, Young Adult, Executive Function
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