The DOI matches its Crossref record, with a small difference in title or year; 7 of the 7 references it cites were found in a registry or an index.
Blood pressure and dementia: What the SPRINT-MIND trial adds and what we still need to know
Open accessAbstract
High blood pressure (BP) has been associated with an increased risk of cerebrovascular disease, stroke, and Alzheimer disease pathology. Epidemiologic studies are consistent in showing that high BP, particularly in midlife, is a risk factor for the development of dementia in late life. However, supporting randomized evidence of the inference that BP-lowering therapy can prevent dementia has been slow in coming over the last 30 years. The most recent randomized trial, the Systolic Blood Pressure Intervention Trial—Memory and Cognition in Decreased Hypertension (SPRINT-MIND), therefore, makes a pivotal contribution to the field, reemphasizing broader public health benefits of BP lowering and directing future research.1
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“The first included randomised controlled trials (RCTs) of any drug to lower blood pressure and reported a reduction in risk of around 10% at marginal significance (RR 0·9, 95% CI 0·9–1·0).”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
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“Four meta-analyses of blood pressure medications to lower high blood pressure with six studies overlap have provided combined estimates of effects. All meta-analyses suggest reduced dementia in those in the interventions arms for outcomes of any dementia as well as clinically diagnosed Alzheimer's disease.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
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“Meta-regression showed risk lowered more if the achieved systolic pressure differential was larger between the intervention and control group.”
From Dementia prevention, intervention, and care: 2020 report of the Lancet Commission (2020) · cites this paper as [81]
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Metadata
- Authors
- Peters, R., Warwick, J., Anstey, K. J., & Anderson, C. S.
- Affiliations
- The George Institute for Global Health (GB)
- Venue
- Neurology
- Published
- 2019-05-21
- Volume
- 92
- Issue
- 21
- Pages
- 1017-1018
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2940519437
- Cited by
- 68
- References
- 7
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 7 · 2023: 8 · 2022: 14 · 2021: 13 · 2020: 13 · 2019: 3
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UNSWorks (UNSW Sydney) (submittedVersion, cc-by-nc-nd)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Warwick Research Archive Portal (University of Warwick) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, public-domain)
- DRYAD (public-domain)
- Funders
- Amgen
- National Institute for Health and Care Research (PDF-2012-05-197)
- Dementia Centre for Research Collaboration
- Medical Research Council
- National Health and Medical Research Council
- National Institute for Dementia Research
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- blood pressure, hypertension, dementia, Alzheimer's disease, cerebrovascular disease, stroke, midlife blood pressure, blood pressure-lowering therapy, dementia prevention, cognitive decline
- MeSH terms
- Antihypertensive Agents, Blood Pressure, Blood Pressure Determination, Dementia, Humans
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