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Incidence of epilepsy: A systematic review and meta-analysis

Open access
Ngugi, A.K., Kariuki, S.M., Bottomley, C., Kleinschmidt, I., Sander, J.W., Newton, C.R.·2011·Neurology

Abstract

OBJECTIVE: To estimate the pooled incidence of epilepsy from published studies and investigate sources of heterogeneity in the estimates. METHODS: We searched online databases for incidence studies and used meta-analytic methods to analyze the data. RESULTS: Thirty-three articles met the entry criteria. The median incidence of epilepsy was 50.4/100,000/year (interquartile range [IQR] 33.6-75.6), while it was 45.0 (IQR 30.3-66.7) for high-income countries and 81.7 (IQR 28.0-239.5) for low- and middle-income countries. Population-based studies had higher incidence estimates than hospital-based studies (p = 0.02) while retrospective study design was associated with lower estimates than prospective studies (p = 0.04). CONCLUSION: We provide data that could potentially be used to assess the burden and analyze the trends in incidence of epilepsy. Our results support the need for large population-based incidence studies of epilepsy.

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Metadata

Authors
Ngugi, A. K., Kariuki, S. M., Bottomley, C., Kleinschmidt, I., Sander, J. W., & Newton, C. R.
Venue
Neurology
Published
2011-09-06
Volume
77
Issue
10
Pages
1005-1012
ISSN
  • 0028-3878 (ISSN-L)
  • 1526-632X
OpenAlex
W2144365512
Cited by
425
References
3
FWCI
12.02
Type
journal article
Language
en
Open access
green

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Ngugi, A. K., Kariuki, S. M., Bottomley, C., Kleinschmidt, I., Sander, J. W., & Newton, C. R. (2011). Incidence of epilepsy: A systematic review and meta-analysis. Neurology. https://doi.org/10.1212/wnl.0b013e31822cfc90

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