Total daily physical activity and the risk of AD and cognitive decline in older adults
Open accessAbstract
OBJECTIVE: Studies examining the link between objective measures of total daily physical activity and incident Alzheimer disease (AD) are lacking. We tested the hypothesis that an objective measure of total daily physical activity predicts incident AD and cognitive decline. METHODS: Total daily exercise and nonexercise physical activity was measured continuously for up to 10 days with actigraphy (Actical®; Philips Healthcare, Bend, OR) from 716 older individuals without dementia participating in the Rush Memory and Aging Project, a prospective, observational cohort study. All participants underwent structured annual clinical examination including a battery of 19 cognitive tests. RESULTS: During an average follow-up of about 4 years, 71 subjects developed clinical AD. In a Cox proportional hazards model adjusting for age, sex, and education, total daily physical activity was associated with incident AD (hazard ratio = 0.477; 95% confidence interval 0.273-0.832). The association remained after adjusting for self-report physical, social, and cognitive activities, as well as current level of motor function, depressive symptoms, chronic health conditions, and APOE allele status. In a linear mixed-effect model, the level of total daily physical activity was associated with the rate of global cognitive decline (estimate 0.033, SE 0.012, p = 0.007). CONCLUSIONS: A higher level of total daily physical activity is associated with a reduced risk of AD.
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Exercise is neuroprotective, delays the onset and progression, and reduces the risk for many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.
“Exercise has also been shown to be neuroprotective, to delay the onset and progression, and reduce the risk for many neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD) [17, 39, 58, 89, 108, 163, 193, 199].”
From The neuropathology of sport (2014) · cites this paper as [17]
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References 29 · Cited by 730
- Authors
- Buchman, A. S., Boyle, P. A., Yu, L., Shah, R. C., Wilson, R. S., & Bennett, D. A.
- Affiliations
- Rush University Medical Center (US)
- Venue
- Neurology
- Published
- 2012-04-24
- Volume
- 78
- Issue
- 17
- Pages
- 1323-1329
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3335448
- OpenAlex
- W2164133449
- Cited by
- 730
- References
- 29
- Citations by year
- 2026: 31 · 2025: 55 · 2024: 58 · 2023: 49 · 2022: 50 · 2021: 56 · 2020: 52 · 2019: 51 · 2018: 48 · 2017: 43 · 2016: 50 · 2015: 58 · 2014: 61 · 2013: 42 · 2012: 24
- FWCI
- 42.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Illinois Department of Public Health (R01AG17917, R01AG34374)
- National Institutes of Health
- National Institute on Aging (R01AG017917, R01-AG-24480, R01-AG34374, R01‐AG17917, R01AG024480, R01AG034374)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, physical activity, actigraphy, cognitive decline, older adults, apolipoprotein E, depressive symptoms, motor function
- MeSH terms
- Activities of Daily Living, Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Educational Status, Energy Metabolism, Female, Humans, Life Style, Male, Motor Activity, Risk Factors, Sex Factors, Exercise, Comorbidity, Causality, Body Mass Index, Proportional Hazards Models, Sex Distribution
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