Decreased iron levels in the temporal cortex in postmortem human brains with Parkinson disease
Open accessAbstract
OBJECTIVE: The present study aimed to evaluate alterations in the levels of iron, divalent metal transporter 1 (DMT1) with the iron-responsive element (IRE), transferrin receptor 1 (TfR1), ferroportin 1 (FPN1), and iron regulatory protein 1 (IRP1) in the temporal cortex of human brains with Parkinson disease (PD). METHODS: Iron content was measured using an ICP-MS 7500CE detector. IRP1, DMT1+IRE, TfR1, and FPN1 expressions were determined by Western blotting. RESULTS: Iron content was significantly lower in the temporal cortex of patients with PD when compared with age-matched healthy controls. Unexpectedly, the levels of DMT1+IRE, TfR1, FPN1, and IRP1 were decreased in the temporal cortex in PD brains. No changes were observed in the temporal cortex of postmortem Alzheimer disease brains. CONCLUSIONS: Iron deprivation and iron-related protein dysregulation suggest that a different iron regulatory mechanism may exist, and that iron redistribution may occur between the temporal cortex and the substantia nigra of patients with PD.
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In the temporal cortex and globus pallidus of patients with Parkinson's disease, a decrease of total iron concentration was detected by inductively coupled plasma mass spectrometry.
“In the temporal cortex and globus pallidus of patients with Parkinson’s disease, a decrease of total iron concentration was detected by inductively coupled plasma mass spectrometry.101,117,130”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [130]
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References 10 · Cited by 46
Research works printed but not linked: 4
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- Authors
- Yu, X., Du, T., Song, N., He, Q., Shen, Y., Jiang, H., & Xie, J.
- Affiliations
- Qingdao University (CN)
- Venue
- Neurology
- Published
- 2013-01-29
- Volume
- 80
- Issue
- 5
- Pages
- 492-495
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3590051
- OpenAlex
- W2032450438
- Cited by
- 46
- References
- 10
- Citations by year
- 2025: 4 · 2024: 4 · 2022: 1 · 2021: 8 · 2020: 2 · 2019: 7 · 2018: 2 · 2017: 5 · 2016: 4 · 2015: 2 · 2014: 4 · 2013: 3
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30930036, 81171207)
- National Institutes of Health
- Fok Ying Tong Education Foundation
- National Key Research and Development Program of China (2011CB504102, 30930036)
- National Institute on Aging (P30-AG-19610, R01AG025888, P30AG019610)
- National Institute of Neurological Disorders and Stroke (U24NS072026)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- Parkinson's disease, iron deficiency, temporal cortex, iron regulatory proteins, DMT1, iron-responsive element, transferrin receptor 1, ferroportin 1, iron regulatory protein 1, iron redistribution, substantia nigra, postmortem brain
- MeSH terms
- Ferroportin, Solute Carrier Family 11, Member 2, Aged, Aged, 80 and over, Alzheimer Disease, Female, Gene Expression Regulation, Humans, Iron, Male, Parkinson Disease, Postmortem Changes, Receptors, Transferrin, Spectrophotometry, Atomic, Temporal Lobe, Antigens, CD, Case-Control Studies, Cation Transport Proteins, Iron-Regulatory Proteins, Iron Regulatory Protein 1
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