Disruption of cerebral networks and cognitive impairment in Alzheimer disease.
Open accessAbstract
Objective To examine the relation between measures of whole-brain white matter connectivity and cognitive performance in patients with early Alzheimer disease (AD) using a network-based approach and to assess whether network parameters provide information that is complementary to conventional MRI markers of AD. Methods Fifty patients (mean age 78.8 ± 7.1 years) with early AD were recruited via a memory clinic. In addition, 15 age-, sex-, and education-matched control participants were used as a reference group. All participants underwent a 3-T MRI scan and cognitive assessment. Diffusion tensor imaging-based tractography was used to reconstruct the brain network of each individual, followed by graph theoretical analyses. Overall network efficiency was assessed by measures of local (clustering coefficient, local efficiency) and global (path length, global efficiency) connectivity. Age-, sex-, and education-adjusted cognitive scores were related to network measures and to conventional MRI parameters (i.e., degree of cerebral atrophy and small-vessel disease). Results The structural brain network of patients showed reduced local efficiency compared to controls. Within the patient group, worse performance in memory and executive functioning was related to decreased local efficiency (r = 0.434; p = 0.002), increased path length (r = -0.538; p Conclusion This study shows that network-based analysis of brain white matter connections provides a novel way to reveal the structural basi…
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Network-based analysis of brain white matter connections can reveal the structural basis of cognitive dysfunction in AD.
“network-based analysis of brain white matter (WM) connections can reveal the structural basis of cognitive dysfunction in AD (Reijmer et al., 2013)”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Reijmer et al., 2013
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References 35 · Cited by 147
- Authors
- Reijmer, Y. D., Leemans, A., Caeyenberghs, K., Heringa, S. M., Koek, H. L., Biessels, G. J., & On behalf of the Utrecht Vascular Cognitive Impairment Study Group
- Affiliations
- From the Department of Neurology (Y.D.R., S.M.H., G.J.B.), Image Sciences Institute (A.L.), and Geriatric Department (H.L.K.), University Medical Center Utrecht, Utrecht, the Netherlands; and Motor Control Laboratory (K.C.), Research Center for Movement Control and Neuroplasticity, KU Leuven, Belgium.
- University Medical Center Utrecht (NL)
- Venue
- Neurology
- Published
- 2013-04-09
- Volume
- 80
- Issue
- 15
- Pages
- 1370-1377
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2040298925
- Cited by
- 147
- References
- 35
- Citations by year
- 2026: 3 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 12 · 2020: 10 · 2019: 9 · 2018: 14 · 2017: 13 · 2016: 13 · 2015: 14 · 2014: 17 · 2013: 5
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- green
- figshare.com
- Licence
- cc-by
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Bank (Australian Catholic University) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- Alzheimer's disease, early Alzheimer's disease, brain networks, white matter connectivity, graph theory, local efficiency, global efficiency, path length, cognitive impairment, memory, executive function, brain atrophy, cerebral small vessel disease, diffusion tensor tractography
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Atrophy, Cerebral Cortex, Cognition Disorders, Female, Humans, Magnetic Resonance Imaging, Male, Memory Disorders, Nerve Fibers, Myelinated, Neural Pathways, Neuropsychological Tests, Statistics as Topic, Case-Control Studies, Imaging, Three-Dimensional, Executive Function
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