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Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value
Open accessAbstract
Elevated amounts of antibodies specific for acetylcholine receptors were detected in 87 percent of sera from 71 patients with myasthenia gravis but not in 175 sera from individuals without myasthenia gravis, including those with other neurologic or autoimmune diseases. Antireceptor antibodies were not directed at the acetylcholine binding site of the receptor. Presence or titer of antibody did not appear to correlate with age, sex, steroid therapy, or duration of symptoms. Myasthenia gravis patients with only ocular symptoms had lower antibody titers, while the majority of titers in myasthenia gravis patients with thymoma exceeded the median titer of the myasthenia gravis group as a whole. Assay of antireceptor antibody should prove a useful test in the diagnosis of myasthenia gravis.
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Citations
Cited by
Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity
Meriggioli, M. N., & Sanders, D. B. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70063-8 · Cited by 894
Lifetime course of myasthenia gravis
Grob, D., Brunner, N., Namba, T., & Pagala, M. (2008) · Muscle & Nerve · doi:10.1002/mus.20950 · Cited by 733
Vincent, A., Palace, J., & Hilton-Jones, D. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05186-2 · Cited by 452
Myasthenia gravis with autoimmune autonomic neuropathy
Vernino, S., Cheshire, W. P., & Lennon, V. A. (2001) · Autonomic Neuroscience · doi:10.1016/s1566-0702(01)00239-9 · Cited by 106
Self-citationThymus alterations and susceptibility to immune checkpoint inhibitor myocarditis
Fenioux, C., Abbar, B., Boussouar, S., Bretagne, M., Power, J. R., Moslehi, J. J., Gougis, P., Amelin, D., Dechartres, A., Lehmann, L. H., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02591-2 · Cited by 83
Metadata
- Authors
- LINDSTROM, J. M., SEYBOLD, M. E., LENNON, V. A., WHITTINGHAM, S., & DUANE, D. D.
- Venue
- Neurology
- Published
- 1976-11
- Volume
- 26
- Issue
- 11
- Pages
- 1054-1054
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W4295682875
- Cited by
- 1,186
- References
- 0
- FWCI
- 30.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value. https://app.cochat.ai/papers/10.1212/wnl.26.11.1054
- The paper
- LINDSTROM, J. M., SEYBOLD, M. E., LENNON, V. A., WHITTINGHAM, S., & DUANE, D. D. (1976). Antibody to acetylcholine receptor in myasthenia gravis: Prevalence, clinical correlates, and diagnostic value. Neurology. https://doi.org/10.1212/wnl.26.11.1054
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
