Cited by 1,526Atrial Fibrillation Management and OutcomesAcute Ischemic Stroke ManagementCardiovascular and Diving-Related Complications

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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The fiamingham Study

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Wolf, Philip A., Dawber, Thomas R., Thomas, H. Emerson, Kannel, William B.·1978·Neurology

DOI 10.1212/wnl.28.10.973

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Abstract

Chronic atrial fibrillation (AF) as a precursor of stroke was assessed over 24 years of follow-up of the general population sample at Framingham, Massachusetts. Persons with chronic established AF, with or without rheumatic heart disease (RHD), are at greatly increased risk of stroke, and the stroke is probably due to embolism. Chronic AF in the absence of RHD is associated with more than a fivefold increase in stroke indicence, while AF with RHD has a 17-fold increase. Stroke occurrence increased as duration of AF increased, with no evidence of a particularly vulnerable period. Chronic idiopathic AF is an important precursor of cerebral embolism. Controlled trials of anticoagulants or antiarrhythmic agents in persons with chronic AF may demonstrate if strokes can be prevented in this highly susceptible group.

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Authors: Wolf, P. A., Dawber, T. R., Thomas, H. E., & Kannel, W. B.
Affiliations: Boston University (US)
ORCID: Wolf, Philip A.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1978-10
Volume: 28
Issue: 10
Pages: 973-973
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.28.10.973
OpenAlex: W2161283927
Semantic Scholar: 36de11b13c1674c0a05e028d89d7b881504127cb
Cited by: 1,526
References: 12
Citations by year: 2026: 15 · 2025: 35 · 2024: 36 · 2023: 49 · 2022: 30 · 2021: 73 · 2020: 53 · 2019: 34 · 2018: 38 · 2017: 44 · 2016: 44 · 2015: 49 · 2014: 43 · 2013: 47 · 2012: 45
FWCI: 4.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
Keywords: chronic atrial fibrillation, stroke risk, cerebral embolism, rheumatic heart disease, idiopathic atrial fibrillation, atrial fibrillation duration, stroke incidence, anticoagulation, antiarrhythmic drugs, Framingham Heart Study
MeSH terms: Adult, Atrial Fibrillation, Cerebrovascular Disorders, Chronic Disease, Embolism, Female, Follow-Up Studies, Humans, Male, Massachusetts, Middle Aged, Rheumatic Heart Disease

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Epidemiologic assessment of chronic atrial fibrillation and risk of stroke: The fiamingham Study

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