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Selective decline in cellular immune response to varicella‐zoster in the elderly
Abstract
The incidence of herpes zoster rises markedly in the aged. We evaluated the hypothesis that cellular immunity to varicella-zoster (VZ) viral antigens may be impaired in aged subjects. We found that the lymphocyte proliferation to VZ antigen was less in older asymptomatic individuals than in normal young controls. In contrast, responses to other antigens did not differ. Antibody titers to VZ were similar in both young and old subjects. Impairment of cellular immunity to VZ, on a population basis, may contribute to the increased risk of herpes zoster in the elderly.
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Citations
Cited by
A Vaccine to Prevent Herpes Zoster and Postherpetic Neuralgia in Older Adults
Oxman, M. N., Levin, M. J., Johnson, G. R., Schmader, K. E., Straus, S. E., Gelb, L. D., Arbeit, R. D., Simberkoff, M. S., Gershon, A. A., Davis, L. E., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa051016 · Cited by 2,412
Arvin, A. M. (1996) · Clinical Microbiology Reviews · doi:10.1128/cmr.9.3.361 · Cited by 1,162
Weller, T. H. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312013092205 · Cited by 493
Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
Levin, M. J., Oxman, M. N., Zhang, J. H., Johnson, G. R., Stanley, H., Hayward, A. R., Caulfield, M. J., Irwin, M. R., Smith, J. G., Clair, J., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/528696 · Cited by 355
The Cellular and Subcellular Bases of Immunosenescence
Thoman, M. L., & Weigle, W. O. (1989) · Advances in Immunology · doi:10.1016/s0065-2776(08)60655-0 · Cited by 318
Metadata
- Authors
- Miller, A. E.
- Venue
- Neurology
- Published
- 1980-06
- Volume
- 30
- Issue
- 6
- Pages
- 582-582
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2034236240
- Cited by
- 277
- References
- 0
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miller, A. E. (1980). Selective decline in cellular immune response to varicella‐zoster in the elderly. Neurology. https://doi.org/10.1212/wnl.30.6.582
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
