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Pharmacologic distinction of different orthostatic hypotension syndromes
Abstract
We studied the pressor responses to vasoactive agents in patients with orthostatic hypotension. Greater-than-normal slopes of the stimulus-response curves in patients with multiple system atrophy (Shy-drager syndrome) and idiopathic orthostatic hypotension (IOH) were consistent with deficient reflex modulation. Patients with IOH also had a shift to the left of the plasma norepinephrine-blood pressure curves, suggesting "denervation supersensitivity." This was consistent with the deficient plasma norepinephrine response to tyramine in these patients. Patients in whom orthostatic hypotension is attended by tachycardia are subsensitive to administered catecholamines, and may suffer from deficient effector organ responsivity.
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Citations
Cited by
Oxidative stress and the pathogenesis of Parkinson's disease
Jenner, P., & Olanow, C. W. (1996) · Neurology · doi:10.1212/wnl.47.6_suppl_3.161s · Cited by 971
Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
Jankovic, J., Gilden, J. L., Hiner, B. C., Kaufmann, H., Brown, D. C., Coghlan, C. H., Rubin, M., & Fouad-Tarazi, F. M. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90230-m · Cited by 396
Orthostatic Hypotension in the Elderly
Desforges, J. F., & Lipsitz, L. A. (1989) · New England Journal of Medicine · doi:10.1056/nejm198910053211407 · Cited by 375
Raj, S. R., Biaggioni, I., Yamhure, P. C., Black, B. K., Paranjape, S. Y., Byrne, D. W., & Robertson, D. (2005) · Circulation · doi:10.1161/01.cir.0000160356.97313.5d · Cited by 286
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Freeman, R. (2006) · Clinical Neurophysiology · doi:10.1016/j.clinph.2005.09.027 · Cited by 262
Metadata
- Authors
- Polinsky, R. J., Kopin, I. J., Ebert, M. H., & Weise, V.
- Venue
- Neurology
- Published
- 1981-01
- Volume
- 31
- Issue
- 1
- Pages
- 1-1
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1998955929
- Cited by
- 296
- References
- 0
- FWCI
- 22.23
- Type
- journal article
- Language
- en
- Open access
- closed
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- Polinsky, R. J., Kopin, I. J., Ebert, M. H., & Weise, V. (1981). Pharmacologic distinction of different orthostatic hypotension syndromes. Neurology. https://doi.org/10.1212/wnl.31.1.1
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
