Eaton‐Lambert syndrome: Acetylcholine and choline acetyltransferase in skeletal muscle
Abstract
In biopsied intercostal muscle from six patients with Eaton-Lambert syndrome, we measured acetylcholine content and release and choline acetyltransferase. Both the spontaneous and the KCl-evoked release of acetylcholine were abnormally low. On the other hand, the acetylcholine content and the level of choline acetyltransferase activity were within the range of values earlier found in healthy human intercostal muscle. These results are consistent with the view that the defect in this syndrome lies not in the synthesis or storage of the transmitter but in the mechanism of release itself.
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Mutation in the CHAT gene is associated with myasthenia gravis.
“The mutation in the CHAT gene is associated with myasthenia gravis which is an autoimmune disease characterized by load dependent muscle weakness (Molenaar et al., 1982).”
From Identification of Candidate Signature Genes and Key Regulators Associated With Trypanotolerance in the Sheko Breed (2019) · cites this paper as Molenaar et al., 1982
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Mekonnen, Y. A., Gültas, M., Effa, K., Hanotte, O., & Schmitt, A. O. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01095 · Cited by 37 · see citing works
- Authors
- Molenaar, P. C., Newsom-Davis, J., Polak, R. L., & Vincent, A.
- Affiliations
- Leiden University Medical Center (NL)
- Department of Pharmacology t Dr. Molenaar). Leiden University Medical Centre, Leiden. The Netherlands, the Department of Neurological Science (Dr. Newsom Davis and Ms. Vincent). Royal Free Hospital, London, United Kingdom, and Medical Biological Laboratory T.N.O. (Dr. Polak), Rijswijk. The Netherlands.
- Venue
- Neurology
- Published
- 1982-09
- Volume
- 32
- Issue
- 9
- Pages
- 1061-1061
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1981889756
- Cited by
- 47
- References
- 0
- Citations by year
- 2023: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2018: 1 · 2017: 1 · 2015: 1
- FWCI
- 6.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Health Sciences › Medicine › Neurology › Peripheral Neuropathies and Disorders
- Keywords
- Lambert-Eaton myasthenic syndrome, acetylcholine release, acetylcholine content, choline acetyltransferase, intercostal muscles, neuromuscular junction, potassium-evoked release
- MeSH terms
- Acetylcholine, Adult, Aged, Choline O-Acetyltransferase, Female, Humans, Male, Middle Aged, Muscles, Myasthenia Gravis, Synaptic Transmission, Neuromuscular Junction, Syndrome
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