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The heterogeneity of Parkinson's disease: Clinical and prognostic implications
Abstract
In 334 patients with idiopathic Parkinson's disease, deterioration in mental status paralleled severity of bradykinesia, postural instability, and gait difficulty. Tremor was relatively independent of the other cardinal signs and was associated with relative preservation of mental status, earlier age at onset, family history of parkinsonism, and more favorable prognosis. There seem to be at least two Parkinson's subgroups: one with postural instability and gait difficulty and another with tremor as the dominant feature.
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Cited by
Clinical diagnostic criteria for dementia associated with Parkinson’s disease
Emre, M., Aarsland, D., Brown, R., Burn, D. J., Duyckaerts, C., Mizuno, Y., Broe, G. A., Cummings, J., Dickson, D. W., Gauthier, S., et al. (2007) · Movement Disorders · doi:10.1002/mds.21507 · Cited by 3,027
What contributes to quality of life in patients with Parkinson's disease?
Schrag, A. (2000) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.69.3.308 · Cited by 1,380
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort
Williams-Gray, C. H., Evans, J. R., Goris, A., Foltynie, T., Ban, M., Robbins, T. W., Brayne, C., Kolachana, B. S., Weinberger, D. R., Sawcer, S. J., et al. (2009) · Brain · doi:10.1093/brain/awp245 · Cited by 965
Cerebral causes and consequences of parkinsonian resting tremor: a tale of two circuits?
Helmich, R. C., Hallett, M., Deuschl, G., Toni, I., & Bloem, B. R. (2012) · Brain · doi:10.1093/brain/aws023 · Cited by 581
Lewis, S. J. G., Dove, A., Robbins, T. W., Barker, R. A., & Owen, A. M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06351.2003 · Cited by 532
Metadata
- Authors
- Zetusky, W. J., Jankovic, J., & Pirozzolo, F. J.
- Venue
- Neurology
- Published
- 1985-04
- Volume
- 35
- Issue
- 4
- Pages
- 522-522
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2072797584
- Cited by
- 380
- References
- 0
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zetusky, W. J., Jankovic, J., & Pirozzolo, F. J. (1985). The heterogeneity of Parkinson's disease: Clinical and prognostic implications. Neurology. https://doi.org/10.1212/wnl.35.4.522
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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