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Low‐dose L‐dopa therapy in Parkinson's disease: A 6‐year follow‐up study
Abstract
Thirty-five patients with early mild Parkinson's disease were treated from the outset with small doses of L-dopa (mean dose, 396 to 454 mg daily) and a peripheral decarboxylase inhibitor, for a mean of 6 years. Overall mortality ratio was 1.2:1, worse for women than for men. After 6 years of treatment, only one-third of patients were better, and drug-related complications were common (peak-dose dyskinesias in 54% of patients, off-period dystonia 20%, wearing-off effects 52%, on-off oscillations 6%, visual hallucinations and toxic confusional states 17%). We found no evidence that long-term results were markedly improved with low-dose regimens.
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Cited by
Ahlskog, J. E., & Muenter, M. D. (2001) · Movement Disorders · doi:10.1002/mds.1090 · Cited by 1,454
Levodopa in the treatment of Parkinson's disease
Schapira, A. H. V., Emre, M., Jenner, P., & Poewe, W. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02697.x · Cited by 231
Self-citationBradley, S. R., Marino, M. J., Wittmann, M., Rouse, S. T., Awad, H., Levey, A. I., & Conn, P. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03085.2000 · Cited by 141
Motor and Nonmotor Complications of Levodopa: Phenomenology, Risk Factors, and Imaging Features
Ray Chaudhuri, K., Poewe, W., & Brooks, D. (2018) · Movement Disorders · doi:10.1002/mds.27386 · Cited by 121
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Metadata
- Authors
- Poewe, W. H., Lees, A. J., & Stern, G. M.
- Venue
- Neurology
- Published
- 1986-11
- Volume
- 36
- Issue
- 11
- Pages
- 1528-1528
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2065015313
- Cited by
- 163
- References
- 0
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Poewe, W. H., Lees, A. J., & Stern, G. M. (1986). Low‐dose L‐dopa therapy in Parkinson's disease: A 6‐year follow‐up study. Neurology. https://doi.org/10.1212/wnl.36.11.1528
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