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Why do frontal lobe symptoms predominate in vascular dementia with lacunes?
Abstract
We studied 30 necropsy cases of vascular dementia with a lacunar state. Manifestations included dementia, lack of volition, emotional lability, small-stepped gait, dysarthria, urinary incontinence, grasp reflex, pyramidal signs, paraplegia in flexion, and akinetic mutism. Pathologically, there was diffuse incomplete softening of white matter in all cases. Both lacunes and diffuse softening were found predominantly in the frontal lobes. The prominent clinical features were therefore frontal lobe symptoms, with good correlation between the symptoms and the distribution of pathologic lesions.
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Cited by
O'Brien, J. T., Erkinjuntti, T., Reisberg, B., Roman, G., Sawada, T., Pantoni, L., Bowler, J. V., Ballard, C., DeCarli, C., Gorelick, P. B., et al. (2003) · The Lancet Neurology · doi:10.1016/s1474-4422(03)00305-3 · Cited by 1,139
Subcortical ischaemic vascular dementia
Román, G. C., Erkinjuntti, T., Wallin, A., Pantoni, L., & Chui, H. C. (2002) · The Lancet Neurology · doi:10.1016/s1474-4422(02)00190-4 · Cited by 1,067
White matter lesions impair frontal lobe function regardless of their location
Tullberg, M., Fletcher, E., DeCarli, C., Mungas, D., Reed, B. R., Harvey, D. J., Weiner, M. W., Chui, H. C., & Jagust, W. J. (2004) · Neurology · doi:10.1212/01.wnl.0000130530.55104.b5 · Cited by 530
Senile Dementia of the Binswanger Type: A Vascular Form of Dementia in the Elderly
Román, G. C. (1987) · JAMA · doi:10.1001/jama.1987.03400130096040 · Cited by 372
The frontal behavioral inventory in the differential diagnosis of frontotemporal dementia
KERTESZ, A., NADKARNI, N., DAVIDSON, W., & THOMAS, A. W. (2000) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617700644041 · Cited by 317
Metadata
- Authors
- Ishii, N., Nishihara, Y., & Imamura, T.
- Venue
- Neurology
- Published
- 1986-03
- Volume
- 36
- Issue
- 3
- Pages
- 340-340
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2055317311
- Cited by
- 293
- References
- 0
- FWCI
- 7.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ishii, N., Nishihara, Y., & Imamura, T. (1986). Why do frontal lobe symptoms predominate in vascular dementia with lacunes? Neurology. https://doi.org/10.1212/wnl.36.3.340
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
