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Positron emission tomography in the early diagnosis of Huntington's disease
Abstract
We studied 10 patients with early Huntington's disease and 7 normal age-matched controls with positron emission tomography (PET) using fluorodeoxyglucose. Subjects had little or no caudate nucleus atrophy and had not received any medications. The results demonstrated that hypometabolism of glucose preceded tissue loss. Furthermore, patients with minimal neurologic or psychiatric symptoms and no obvious CT changes may be differentiated from normal persons with high accuracy by PET. PET is helpful in the early diagnosis of Huntington's disease irrespective of the mode of presentation. PET may also be useful for preclinical detection and may supplement information from DNA studies.
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“Positron emission tomography brain imaging with [18 F]-fluorodeoxyglucose has revealed a regional decrease of glucose usage in the striatum (caudate and putamen) and cortex (frontal and temporal lobes) of persons symptomatic and at risk for HD [3-8].”
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Grafton, S. T., Mazziotta, J. C., Pahl, J. J., George-Hyslop, P. S., Haines, J. L., Gusella, J., Hoffman, J. M., Baxter, L. R., & Phelps, M. E. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530350075022 · Cited by 157
McClory, H., Williams, D., Sapp, E., Gatune, L. W., Wang, P., DiFiglia, M., & Li, X. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0178-7 · Cited by 60
Metadata
- Authors
- Hayden, M. R., Martin, W. R. W., Stoessl, A. J., Clark, C., Hollenberg, S., Adam, M. J., Ammann, W., Harrop, R., Rogers, J., Ruth, T., Sayre, C., & Pate, B. D.
- Affiliations
- Department of Medical Genetics and Internal Medicine (Drs. Hayden and Hollenberg), Division of Neurology (Drs. Martin and Stoessl), Department of Psychiatry (Dr. Clark), and the UBC/Triumf PET Group (Drs. Martin, Adam, Ammann, Harrop, Rogers, Ruth, Sayre, and Pate), University of British Columbia, Vancouver, BC, Canada.
- Venue
- Neurology
- Published
- 1986-07
- Volume
- 36
- Issue
- 7
- Pages
- 888-888
- ISSN
- 0028-3878
- 1526-632X
- Cited by
- 159
- References
- 0
- Language
- en
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- CoChat. (2026). Citation check: Positron emission tomography in the early diagnosis of Huntington's disease. https://app.cochat.ai/papers/10.1212/wnl.36.7.888
- The paper
- Hayden, M. R., Martin, W. R. W., Stoessl, A. J., Clark, C., Hollenberg, S., Adam, M. J., Ammann, W., Harrop, R., Rogers, J., Ruth, T., Sayre, C., & Pate, B. D. (1986). Positron emission tomography in the early diagnosis of Huntington's disease. Neurology. https://doi.org/10.1212/wnl.36.7.888
