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Seizures and myoclonus in patients with Alzheimer's disease
Abstract
We reviewed 81 patients with dementia and autopsy findings of Alzheimer's disease (AD) to identify patients with seizures or myoclonus after onset of dementia. Eight (10%) had seizures, and eight others (10%) had myoclonus. The incidence of seizures was 10 times more than expected in a reference population. Seizures occurred in any stage of AD, but myoclonus was often a late manifestation. Both seizures and myoclonus, individually or together, are manifestations of AD and may be seen at any time in the course of the illness.
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“Loss of inhibitory neurons would naturally be expected to disrupt excitatory and inhibitory balance; impaired inhibition may therefore increase the susceptibility of patients with AD to epilepsy, a clinical symptom found in more than 10% of patients88.”
From Integrated multimodal cell atlas of Alzheimer’s disease (2024) · cites this paper as [88]
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Palop, J. J., Chin, J., Roberson, E. D., Wang, J., Thwin, M. T., Bien-Ly, N., Yoo, J., Ho, K. O., Yu, G.-Q., Kreitzer, A., et al. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.025 · Cited by 1,653
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216
The Genetic Defect Causing Familial Alzheimer's Disease Maps on Chromosome 21
George‐Hyslop, P. S., Tanzi, R. E., Polinsky, R. J., Haines, J. L., Nee, L. E., Watkins, P. C., Myers, R. H., Feldman, R. G., Pollen, D. A., Drachman, D. A., et al. (1987) · Science · doi:10.1126/science.2880399 · Cited by 1,160
Network abnormalities and interneuron dysfunction in Alzheimer disease
Palop, J. J., & Mucke, L. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.141 · Cited by 1,022
Seizures and Epileptiform Activity in the Early Stages of Alzheimer Disease
Vossel, K. A., Beagle, A. J., Rabinovici, G., Shu, H., Lee, S. E., Naasan, G., Hegde, M., Cornes, S., Henry, M., Nelson, A. B., et al. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.136 · Cited by 709
Metadata
- Authors
- Hauser, W. A., Morris, M. L., Heston, L. L., & Anderson, V. E.
- Affiliations
- University of Minnesota (US)
- ORCID
- Hauser, W. Allen
- Venue
- Neurology
- Published
- 1986-09
- Volume
- 36
- Issue
- 9
- Pages
- 1226-1226
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2010891279
- Cited by
- 336
- References
- 0
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 8 · 2023: 10 · 2022: 13 · 2021: 15 · 2020: 18 · 2019: 15 · 2018: 12 · 2017: 12 · 2016: 15 · 2015: 11 · 2014: 7 · 2013: 8 · 2012: 18
- FWCI
- 3.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (1-P50-NS16308, P50NS016308)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- Alzheimer's disease, seizures, myoclonus, dementia, autopsy findings, seizure incidence, late-stage dementia
- MeSH terms
- Aged, Alzheimer Disease, Epilepsies, Myoclonic, Humans, Middle Aged, Seizures
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