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Valproic acid hepatic fatalities: A retrospective review
Abstract
We reviewed all US cases of fatal hepatotoxicity coincident with valproate anticonvulsant therapy that were reported between 1978 and 1984. Thirty-seven hepatic fatalities were determined to have occurred coincident with the use of valproate. All but one patient had such other medical conditions as mental retardation, developmental delay, congenital abnormalities, and other neurologic diseases. The primary risk of fatal hepatic dysfunction (1/500) was found to be in children 0 to 2 years old receiving valproate as polytherapy. The risk declined with age and was low in patients receiving valproate as monotherapy (1/37,000). No hepatic fatalities occurred in patients above the age of 10 years receiving valproate as monotherapy.
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Citations
Cited by
Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
Fromenty, B., & Pessayre, D. (1995) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)00012-6 · Cited by 665
The importance of drug interactions in epilepsy therapy
Patsalos, P. N., Fröscher, W., Pisani, F., & Van Rijn, C. M. (2002) · Epilepsia · doi:10.1046/j.1528-1157.2002.13001.x · Cited by 455
Children versus adults: pharmacokinetic and adverse-effect differences
Anderson, G. D. (2002) · Epilepsia · doi:10.1046/j.1528-1157.43.s.3.5.x · Cited by 187
Carnitine transport: Pathophysiology and metabolism of known molecular defects
Tein, I. (2003) · Journal of Inherited Metabolic Disease · doi:10.1023/a:1024481016187 · Cited by 140
Established anticonvulsants and treatment of refractory epilepsy
Brodie, M. J. (1990) · The Lancet · doi:10.1016/0140-6736(90)91886-f · Cited by 100
Metadata
- Authors
- Dreifuss, F. E., Santilli, N., Langer, D. H., Sweeney, K. P., Moline, K. A., & Menander, K. B.
- Venue
- Neurology
- Published
- 1987-03
- Volume
- 37
- Issue
- 3
- Pages
- 379-379
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1977307548
- Cited by
- 483
- References
- 0
- FWCI
- 22.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Dreifuss, F. E., Santilli, N., Langer, D. H., Sweeney, K. P., Moline, K. A., & Menander, K. B. (1987). Valproic acid hepatic fatalities: A retrospective review. Neurology. https://doi.org/10.1212/wnl.37.3.379
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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