The DOI matches its Crossref record.
Cytomegalovirus polyradiculoneuropathy in acquired immune deficiency syndrome.
Abstract
A 34-year-old homosexual man with acquired immune deficiency syndrome developed extraocular muscle deficits, chorioretinitis, and paraplegia without sensory symptoms. EMG showed severe diffuse denervation, but only mildly slowed nerve conduction velocities, in both legs. Meningitis persisted for 6 weeks and was exacerbated prior to the patient's death. Necropsy revealed subpial and subependymal cytomegalovirus (CMV) infection. Histology of ventral roots demonstrated proximal CMV infection and massive fiber loss. In this immunosuppressed patient, CMV caused a severe motor polyradiculopathy by selective destruction of the motor neurons of ventral spinal roots and motor cranial nerves.
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Metadata
- Authors
- Behar, R., Wiley, C., & McCutchan, J. A.
- Affiliations
- University of California San Diego (US)
- Venue
- Neurology
- Published
- 1987-04
- Volume
- 37
- Issue
- 4
- Pages
- 557-557
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1993224456
- Cited by
- 137
- References
- 0
- Citations by year
- 2023: 2 · 2022: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 3 · 2012: 2
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Health Sciences › Medicine › Clinical Neurology › Peripheral Neuropathies and Disorders
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Keywords
- cytomegalovirus infection, polyradiculoneuropathy, AIDS, paraplegia, chorioretinitis, immunosuppression, denervation
- MeSH terms
- Acquired Immunodeficiency Syndrome, Adult, Cerebral Ventricles, Cranial Nerve Diseases, Cytomegalovirus Infections, Humans, Male, Oculomotor Nerve, Polyradiculoneuropathy
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