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The risk of unprovoked seizures after encephalitis and meningitis
Abstract
A population-based cohort of 714 survivors of encephalitis or meningitis between 1935 and 1981 was followed in order to evaluate the risks of unprovoked seizures after CNS infections. The 20-year risk of developing unprovoked seizures was 6.8%, and the ratio of observed to expected cases of unprovoked seizures was 6.9. The increased incidence of unprovoked seizures was highest during the first 5 years after the CNS infection but remained elevated over the next 15 years of follow-up. The type of CNS infection and the presence or absence of seizures during the acute phase of the CNS infection greatly influenced the risks of subsequent unprovoked seizures. The 20-year risk of developing unprovoked seizures was 22% for patients with viral encephalitis and early seizures, 10% for patients with viral encephalitis without early seizures, 13% for patients with bacterial meningitis and early seizures, and 2.4% for patients with bacterial meningitis without early seizures. The 20-year risk of 2.1% for patients with aseptic meningitis was not increased over the general population incidence of unprovoked seizures.
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Citations
Cited by
A population-based study of seizures after traumatic brain injuries
Annegers, J. F., Hauser, W. A., Coan, S. P., & Rocca, W. A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801013380104 · Cited by 1,090
Self-citationEpilepsy in poor regions of the world
Newton, C. R., & Garcia, H. H. (2012) · The Lancet · doi:10.1016/s0140-6736(12)61381-6 · Cited by 493
Intractable epilepsy: management and therapeutic alternatives
Schuele, S. U., & Lüders, H. O. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70108-x · Cited by 344
Risk of unprovoked seizure after acute symptomatic seizure: Effect of status epilepticus
Hesdorffer, D. C., Logroscino, G., Cascino, G., Annegers, J. F., & Hauser, W. A. (1998) · Annals of Neurology · doi:10.1002/ana.410440609 · Cited by 300
Self-citationCommonalities in epileptogenic processes from different acute brain insults: Do they translate?
Klein, P., Dingledine, R., Aronica, E., Bernard, C., Blümcke, I., Boison, D., Brodie, M. J., Brooks‐Kayal, A. R., Engel, J., Forcelli, P. A., et al. (2018) · Epilepsia · doi:10.1111/epi.13965 · Cited by 284
Metadata
- Authors
- Annegers, J. F., Hauser, W. A., Beghi, E., Nicolosi, A., & Kurland, L. T.
- Venue
- Neurology
- Published
- 1988-09
- Volume
- 38
- Issue
- 9
- Pages
- 1407-1407
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1971971292
- Cited by
- 324
- References
- 0
- FWCI
- 1.48
- Type
- journal article
- Language
- en
- Open access
- closed
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- Annegers, J. F., Hauser, W. A., Beghi, E., Nicolosi, A., & Kurland, L. T. (1988). The risk of unprovoked seizures after encephalitis and meningitis. Neurology. https://doi.org/10.1212/wnl.38.9.1407
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
