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Persistent neurotoxicity of systemically administered interferon‐alpha
Abstract
Fourteen cancer patients had evidence of persistent neurotoxicity of interferon-alpha therapy long after their treatment was discontinued. Although most of the cognitive symptoms were mild to moderate in severity, they were incapacitating to these individuals in their usual work. The neuropsychological test abnormalities were not attributable to subsequent therapy, disease status, or other medical problems. The pattern of deficits was consistent with frontal-subcortical dysfunction. Of the four patients who had follow-up assessment, two had improved and two had deteriorated. These findings suggest that in some cases interferon neurotoxicity is not reversible.
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Citations
Cited by
Capuron, L. (2002) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00407-9 · Cited by 797
Neuroendocrine-Immune Mechanisms of Behavioral Comorbidities in Patients With Cancer
Miller, A. H., Ancoli-Israel, S., Bower, J. E., Capuron, L., & Irwin, M. R. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.10.7805 · Cited by 608
Neuropsychiatric Adverse Effects of Interferon-??: Recognition and Management
Raison, C. L., Demetrashvili, M., Capuron, L., & Miller, A. H. (2005) · CNS Drugs · doi:10.2165/00023210-200519020-00002 · Cited by 483
Spastic diplegia as a complication of interferon Alfa-2a treatment of hemangiomas of infancy
Barlow, C. F., Priebe, C. J., Mulliken, J. B., Barnes, P. D., Mac Donald, D., Folkman, J., & Ezekowitz, R. A. B. (1998) · The Journal of Pediatrics · doi:10.1016/s0022-3476(98)70034-4 · Cited by 441
Role of Inflammation in Suicide: From Mechanisms to Treatment
Brundin, L., Bryleva, E. Y., & Thirtamara Rajamani, K. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.116 · Cited by 257
“It is well established that ~ 30 – 45% of patients receiving IFN treatment develop depressive-like symptoms during the course of therapy, with a proportion of them experiencing these symptoms long after therapy has ceased (Meyers et al , 1991; Miyaoka et al , 1999).”
Metadata
- Authors
- Meyers, C. A., Scheibel, R. S., & Forman, A. D.
- Venue
- Neurology
- Published
- 1991-05
- Volume
- 41
- Issue
- 5
- Pages
- 672-676
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2093896551
- Cited by
- 208
- References
- 0
- FWCI
- 9.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meyers, C. A., Scheibel, R. S., & Forman, A. D. (1991). Persistent neurotoxicity of systemically administered interferon‐alpha. Neurology. https://doi.org/10.1212/wnl.41.5.672
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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