The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Paraneoplastic cerebellar degeneration.: I.A clinical analysis of 55 anti‐Yo antibody‐positive patients
Abstract
We reviewed the clinical findings in 55 patients with cerebellar degeneration associated with the anti-Yo antibody (an anti-Purkinje cell antibody identified in this study by histochemistry and Western blot). The patients were all women, 26 to 85 years old. Fifty-two of them proved to have malignancies, almost exclusively breast or gynecologic cancers and usually confined to the involved organs and local lymph nodes. One woman had adenocarcinoma of the lung, and in three no malignancy has yet been identified. In 34 of 52 patients with cancer, the neurologic syndrome preceded the diagnosis of cancer and in many led to that diagnosis. Patients subacutely developed a pancerebellar disorder that was substantially disabling in most, with 37 of 48 assessable patients being unable to walk or sit unassisted. Laboratory evaluation revealed lymphocytic pleocytosis in 35 patients, with eventual cerebellar atrophy on imaging studies in seventeen. The disabling neurologic syndrome generally did not respond to treatment, but the cancer was often successfully treated. The presence of the anti-Yo antibody in patients with cerebellar symptoms warrants an aggressive approach to diagnosis and treatment of the underlying cancer, as many are curable at the time neurologic symptoms develop.
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Dalmau, J., Graus, F., Rosenblum, M. K., & Posner, J. B. (1992) · MEDICINE · doi:10.1097/00005792-199203000-00001 · Cited by 819
Self-citationFurneaux, H. M., Rosenblum, M. K., Dalmau, J., Wong, E., Woodruff, P., Graus, F., & Posner, J. B. (1990) · New England Journal of Medicine · doi:10.1056/nejm199006283222604 · Cited by 287
Self-citationAutoantibodies in paraneoplastic syndromes associated with small‐cell lung cancer
Anderson, N. E., Rosenblum, M. K., Graus, F., Wiley, R. G., & Posner, J. B. (1988) · Neurology · doi:10.1212/wnl.38.9.1391 · Cited by 252
Self-citationSUBACUTE CORTICAL CEREBELLAR DEGENERATION AND ITS RELATION TO CARCINOMA
Brain, W. R., Daniel, P. M., & Greenfield, J. G. (1951) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.14.2.59 · Cited by 196
Jaeckle, K. A., Graus, F., Houghton, A., Cardon‐Cardo, C., Nielsen, S. L., & Posner, J. B. (1985) · Annals of Neurology · doi:10.1002/ana.410180513 · Cited by 178
Self-citationSUBACUTE CEREBELLAR DEGENERATION ASSOCIATED WITH NEOPLASMS
BRAIN, L., & WILKINSON, M. (1965) · Brain · doi:10.1093/brain/88.3.465 · Cited by 170
Graus, F., Illa, I., Agusti, M., Ribalta, T., Cruz-Sanchez, F., & Juarez, C. (1991) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(91)90198-g · Cited by 163
Dropcho, E. J., Chen, Y. T., Posner, J. B., & Old, L. J. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.13.4552 · Cited by 162
Self-citationFathallah‐Shaykh, H. M., Wolf, S., Wong, E., Posner, J. B., & Furneaux, H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3451 · Cited by 146
Self-citationGreenlee, J., & Lipton, H. L. (1986) · Annals of Neurology · doi:10.1002/ana.410190117 · Cited by 79
Cited by
Paraneoplastic syndromes of the CNS
Dalmau, J., & Rosenfeld, M. R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70060-7 · Cited by 873
(2000) · PubMed · Cited by 94
Staffaroni, A., Elahi, F., McDermott, D., Marton, K., Karageorgiou, E., Sacco, S., Paoletti, M., Caverzasi, E., Hess, C., Rosen, H., et al. (2017) · Seminars in Neurology · doi:10.1055/s-0037-1608808 · Cited by 91
Metadata
- Authors
- MD, K. P., Rosenblum, M. K., MS, H. K., & Posner, J. B.
- Venue
- Neurology
- Published
- 1992-10
- Volume
- 42
- Issue
- 10
- Pages
- 1931-1931
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2092226919
- Cited by
- 608
- References
- 14
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- MD, K. P., Rosenblum, M. K., MS, H. K., & Posner, J. B. (1992). Paraneoplastic cerebellar degeneration.: I.A clinical analysis of 55 anti‐Yo antibody‐positive patients. Neurology. https://doi.org/10.1212/wnl.42.10.1931
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