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Human walking and higher‐level gait disorders, particularly in the elderly
Abstract
A 15-year-old boy on a vegetarian diet presented with severe macrocytic anaemia (haemoglobin, 5.1 g/dL; mean corpuscular volume, 116 fL) in addition to leucopenia and thrombocytopaenia (pancytopenia), icterus secondary to haemolysis and splenomegaly. Laboratory investigations revealed severe vitamin B12 (cobalamin) deficiency. Following cobalamin replacement therapy, the patient reported increased well-being, including appetite and weight gain, and his icterus resolved. In the follow-up laboratory examinations, leucocyte and platelet counts in addition to serum bilirubin and lactate dehydrogenase levels normalised. At the end of 2 months, laboratory findings, including haemoglobin level, were all within the normal range. We present this case as a reminder that severe vitamin B12 deficiency may present with findings mimicking acute leukaemia (pancytopenia and splenomegaly) and findings suggestive of pseudothrombotic microangiopathy.
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Citations
Cited by
Attention and the control of posture and gait: a review of an emerging area of research
Woollacott, M., & Shumway-Cook, A. (2002) · Gait & Posture · doi:10.1016/s0966-6362(01)00156-4 · Cited by 2,690
Cortical Mapping of Gait in Humans: A Near-Infrared Spectroscopic Topography Study
Miyai, I., Tanabe, H. C., Sase, I., Eda, H., Oda, I., Konishi, I., Tsunazawa, Y., Suzuki, T., Yanagida, T., & Kubota, K. (2001) · NeuroImage · doi:10.1006/nimg.2001.0905 · Cited by 788
Prevalence of Parkinsonian Signs and Associated Mortality in a Community Population of Older People
Bennett, D. A., Beckett, L. A., Murray, A. M., Shannon, K. M., Goetz, C. G., Pilgrim, D. M., & Evans, D. A. (1996) · New England Journal of Medicine · doi:10.1056/nejm199601113340202 · Cited by 659
Comparative analysis of the gait disorder of normal pressure hydrocephalus and Parkinson's disease
Stolze, H. (2001) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.70.3.289 · Cited by 369
The gait disorder of advanced essential tremor
Stolze, H. (2001) · Brain · doi:10.1093/brain/124.11.2278 · Cited by 275
Metadata
- Authors
- Nutt, J. G., Marsden, C. D., & Thompson, P. D.
- Venue
- Neurology
- Published
- 1993-02
- Volume
- 43
- Issue
- 2
- Pages
- 268-268
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2065363897
- Cited by
- 674
- References
- 0
- FWCI
- 8.54
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nutt, J. G., Marsden, C. D., & Thompson, P. D. (1993). Human walking and higher‐level gait disorders, particularly in the elderly. Neurology. https://doi.org/10.1212/wnl.43.2.268
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