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Duchenne muscular dystrophy: Deficiency of dystrophin‐associated proteins in the sarcolemma
Abstract
Dystrophin, the protein product of the Duchenne muscular dystrophy (DMD) gene, is a major component of the subsarcolemmal cytoskeleton and exists in a large oligomeric complex tightly associated with several sarcolemmal glycoproteins which provide a linkage to the extracellular matrix protein, laminin. In the present study, we investigated the status of the dystrophin-associated proteins in the skeletal muscle from 17 DMD patients of various ages. The results revealed a dramatic reduction in all of the dystrophin-associated proteins in the sarcolemma of DMD muscle compared with normal muscle and muscle from a variety of other neuromuscular diseases. This abnormality was common in all 17 DMD patients, irrespective of age. Our results indicate that the absence of dystrophin leads to the loss in all of the dystrophin-associated proteins, which renders DMD muscle fibers susceptible to necrosis. The analysis of dystrophin-associated proteins is important in the assessment of experimental therapies that attempt to replace dystrophin in DMD muscle.
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Citations
Cited by
Utrophin–dystrophin-deficient mice as a model for Duchenne muscular dystrophy
Deconinck, A. E., Rafael, J. A., Skinner, J. A., Brown, S. C., Potter, A. C., Metzinger, L., Watt, D. J., Dickson, J. G., Tinsley, J. M., & Davies, K. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80532-2 · Cited by 752
Expression of full-length utrophin prevents muscular dystrophy in mdx mice
Tinsley, J., Deconinck, N., Fisher, R., Kahn, D., Phelps, S., Gillis, J.-M., & Davies, K. (1998) · Nature Medicine · doi:10.1038/4033 · Cited by 615
Dystroglycan-α, a dystrophin-associated glycoprotein, is a functional agrin receptor
Gee, S. H., Montanaro, F., Lindenbaum, M. H., & Carbonetto, S. (1994) · Cell · doi:10.1016/0092-8674(94)90052-3 · Cited by 512
Missense mutations in the adhalin gene linked to autosomal recessive muscular dystrophy
Roberds, S. L., Leturcq, F., Allamand, V., Piccolo, F., Jeanpierre, M., Anderson, R. D., Lim, L. E., Lee, J. C., Tomé, F. M. S., Romero, N. B., et al. (1994) · Cell · doi:10.1016/0092-8674(94)90527-4 · Cited by 454
Self-citationRando, T. A. (2001) · Muscle & Nerve · doi:10.1002/mus.1192 · Cited by 424
Metadata
- Authors
- Ohlendieck, K., Matsumura, K., Ionasescu, V. V., Towbin, J. A., Bosch, E. P., Weinstein, S. L., Sernett, S. W., & Campbell, K. P.
- Venue
- Neurology
- Published
- 1993-04
- Volume
- 43
- Issue
- 4
- Pages
- 795-795
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2048864017
- Cited by
- 260
- References
- 0
- FWCI
- 9.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Duchenne muscular dystrophy: Deficiency of dystrophin‐associated proteins in the sarcolemma. https://app.cochat.ai/papers/10.1212/wnl.43.4.795
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- Ohlendieck, K., Matsumura, K., Ionasescu, V. V., Towbin, J. A., Bosch, E. P., Weinstein, S. L., Sernett, S. W., & Campbell, K. P. (1993). Duchenne muscular dystrophy: Deficiency of dystrophin‐associated proteins in the sarcolemma. Neurology. https://doi.org/10.1212/wnl.43.4.795
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