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Cerebral microembolism in symptomatic and asymptomatic high‐grade internal carotid artery stenosis
Abstract
Using transcranial Doppler (TCD) ultrasonography in patients with high-grade (> or = 70%) internal carotid artery (ICA) stenosis, we examined the relation between the rate of TCD-detected silent microembolism of the ipsilateral middle cerebral artery and a history of recent (< 121 days) ischemic symptoms attributable to the diseased ICA. In the so-defined neurologically symptomatic group (n = 33 patients), silent microembolic events occurred in 27 subjects (overall mean rate, 14/h +/- 29). Among 56 neurologically asymptomatic patients matched for the degree of ICA stenosis, only nine showed such events (overall mean rate, 0.35/h +/- 1.4). Across all 89 patients studied, an individual microembolic event rate > or = 2/h had a positive predictive value of 0.88 for a history of recent symptoms. Our data suggest that TCD monitoring can provide reliable paraclinical evidence of "unstable ICA disease."
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Cited by
Caplan, L. R., & Hennerici, M. (1998) · Archives of Neurology · doi:10.1001/archneur.55.11.1475 · Cited by 869
Sitzer, M., Müller, W., Siebler, M., Hort, W., Kniemeyer, H.-W., Jäncke, L., & Steinmetz, H. (1995) · Stroke · doi:10.1161/01.str.26.7.1231 · Cited by 340
Self-citationAsymptomatic Embolization Predicts Stroke and TIA Risk in Patients With Carotid Artery Stenosis
Molloy, J., & Markus, H. S. (1999) · Stroke · doi:10.1161/01.str.30.7.1440 · Cited by 301
Wong, K. S., Gao, S., Chan, Y. L., Hansberg, T., Lam, W. W. M., Droste, D. W., Kay, R., & Ringelstein, E. B. (2002) · Annals of Neurology · doi:10.1002/ana.10250 · Cited by 268
Metadata
- Authors
- Siebler, M., Kleinschmidt, A., Sitzer, M., Steinmetz, H., & Freund, H.-J.
- Venue
- Neurology
- Published
- 1994-04
- Volume
- 44
- Issue
- 4
- Pages
- 615-615
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1970057679
- Cited by
- 194
- References
- 0
- FWCI
- 16.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cerebral microembolism in symptomatic and asymptomatic high‐grade internal carotid artery stenosis. https://app.cochat.ai/papers/10.1212/wnl.44.4.615
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- Siebler, M., Kleinschmidt, A., Sitzer, M., Steinmetz, H., & Freund, H.-J. (1994). Cerebral microembolism in symptomatic and asymptomatic high‐grade internal carotid artery stenosis. Neurology. https://doi.org/10.1212/wnl.44.4.615
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