Cited by 334Menopause: Health Impacts and TreatmentsDementia and Cognitive Impairment ResearchEstrogen and related hormone effects

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Cognitive function in nondemented older women who took estrogen after menopause

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Jacobs, D. M., Tang, M.-X., Stern, Y., Sano, M., Marder, K., Bell, K. L., Schofield, P., Dooneief, G., Gurland, B., Mayeux, R.·1998·Neurology

DOI 10.1212/wnl.50.2.368

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Abstract

Investigations of the effects of estrogen replacement on cognitive function in healthy older women have yielded disparate results. We evaluated the relationship between a history of estrogen use and cognitive test performance in 727 women participating in a large community-based study. Participants were followed longitudinally for an average of 2.5 years. Estrogen use history was obtained at baseline. Standardized tests of memory, language, and abstract reasoning were administered at baseline and at follow-up. Results indicate that women who had used estrogen replacement scored significantly higher on cognitive testing at baseline than nonusers, and their performance on verbal memory improved slightly over time. The effect of estrogen on cognition was independent of age, education, ethnicity, and APOE genotype. Results suggest that estrogen replacement therapy may help to maintain cognitive function in nondemented postmenopausal women.

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Self-citation

Authors: Jacobs, D. M., Tang, M.-X., Stern, Y., Sano, M., Marder, K., Bell, K. L., Schofield, P., Dooneief, G., Gurland, B., & Mayeux, R.
Affiliations: From the Gertrude H. Sergievsky Center (Drs. Jacobs, Tang, Stem, Sano, Marder, Bell, Schofield, Dooneief, and Mayeux), the Departments of Neurology (Drs. Jacobs, Tang, Stem, Sano, Marder, Bell, Schofield, Dooneief, and Mayeux) and Psychiatry (Drs. Stem, Gurland, and Mayeux), the Taub Center for Alzheimer's Disease Research (Drs. Jacobs, Stern, Sano, Marder, Bell, Dooneief, and Mayeux), the Stroud Center for the Study of Quality of Life (Dr. Gurland), and the Division of Epidemiology (School of...
ORCID: Jacobs, D. M.
Tang, M.-X.
Stern, Y.
Sano, M.
Marder, K.
Bell, K. L.
Schofield, P.
Mayeux, R.
Venue: Neurology
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1998-02
Volume: 50
Issue: 2
Pages: 368-373
ISSN: 0028-3878 (ISSN-L)
1526-632X
DOI: 10.1212/wnl.50.2.368
OpenAlex: W2011716448
Semantic Scholar: 992b97bdcb25a40b827b0415db691b48e6fc9263
Cited by: 332
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 8 · 2020: 1 · 2019: 4 · 2018: 6 · 2017: 6 · 2016: 6 · 2015: 11 · 2014: 4 · 2013: 4 · 2012: 7
FWCI: 16.22
Type: journal article
Language: en
Open access: green
doi.org
Locations: Neurology (publishedVersion)
PubMed (publishedVersion)
Columbia Academic Commons (Columbia University)
Funders: National Institute on Aging (AG08702, P01AG007232, AG 07232, P50AG008702, AG10963, R35AG010963)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Keywords: estrogen replacement therapy, cognitive function, postmenopausal women, menopause, verbal memory, language, abstract thinking, APOE genotype
MeSH terms: Aged, Apolipoproteins E, Cognition, Female, Genotype, Medicare, Humans, Language, Longitudinal Studies, Memory, Speech, United States, Estrogen Replacement Therapy, Case-Control Studies, Postmenopause

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Cognitive function in nondemented older women who took estrogen after menopause

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