The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension
Abstract
OBJECTIVE: To determine the best therapeutic strategy for the use of midodrine in patients with neurogenic orthostatic hypotension (NOH). BACKGROUND: Midodrine is a peripherally acting alpha-adrenergic agonist useful in the treatment of NOH. However, neither the most effective dosage of midodrine nor the required frequency of administration is established. DESIGN/METHODS: Midodrine dose-blood pressure response, pharmacokinetics, and duration of action were examined in a double-blind, placebo-controlled, four-way crossover trial. Twenty-five patients with NOH were randomized to receive on successive days placebo or midodrine 2.5, 10, or 20 mg. Blood pressures of patients in the supine and standing positions were measured sequentially. A global assessment of the patient's overall symptom improvement after each leg of the study was performed. Blood levels of midodrine and its active metabolite, desglymidodrine, were assayed. RESULTS: Midodrine significantly increased standing systolic blood pressure, with the increase peaking at 1 hour. There was a significant linear relation between midodrine dosage and mean systolic blood pressure. The mean score for global improvement of symptoms was significantly higher for midodrine (10 and 20 mg) compared with placebo. The half-life of desglymidodrine was approximately 4 hours. CONCLUSION: A 10-mg dose of midodrine prescribed two to three times daily is effective in increasing orthostatic blood pressure and ameliorating symptoms in patients with NOH.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“There is no doubt that midodrine increases BP both in the supine and upright posture, and ameliorates the symptoms of OH.”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [326]
In the citing paper
“Midodrine (2.5-10 mg t.i.d) was shown to be effective in three randomized placebo-controlled trials. 324-326”
From 2018 ESC Guidelines for the diagnosis and management of syncope (2018) · cites this paper as [326]
Citations
Cites
Neurogenic orthostatic hypotension: a double-blind, placebo-controlled study with midodrine
Jankovic, J., Gilden, J. L., Hiner, B. C., Kaufmann, H., Brown, D. C., Coghlan, C. H., Rubin, M., & Fouad-Tarazi, F. M. (1993) · The American Journal of Medicine · doi:10.1016/0002-9343(93)90230-m · Cited by 396
Self-citationMcTavish, D., & Goa, K. L. (1989) · Drugs · doi:10.2165/00003495-198938050-00004 · Cited by 160
Kaufmann, H., Brannan, T. S., Krakoff, L. R., Yahr, M. D., & Mandeli, J. (1988) · Neurology · doi:10.1212/wnl.38.6.951 · Cited by 136
Self-citationPharmacodynamics of midodrine, an antihypotensive agent
Zachariah, P. K., Bloedow, D. C., Moyer, T. P., Sheps, S. G., SCHIRGER, A., & Fealey, R. D. (1986) · Clinical Pharmacology & Therapeutics · doi:10.1038/clpt.1986.101 · Cited by 57
[The bioavailability of midodrin and alpha-2,5-dimethoxyphenyl-beta-aminoethanol hydrochloride].
Grobecker, H., Kees, F., Linden, M., Schrader, E., & Welte, S. (1987) · PubMed · Cited by 10
Research works printed but not linked: 5
- Thomas JE, Schirger A. Idiopathic orthostatic hypotension. A study of its natural history in 57 neurologically affected persons. Arch Neurol 1970;22:289-293.
- Cohen J, Low P, Fealey R, Sheps S, Jiang N-S. Somatic and autonomic function in progressive autonomic failure and multiple system atrophy. Ann Neurol 1987;22:692-699.
- Thulesius O, Gjores JE, Berlin E. Vasoconstrictor effect of midodrine, ST 1059, noradrenaline, etilefrine and dihydroergotamine on isolated human veins. Eur J Clin Pharmacol 1979;16:423-424.
- Schatz IJ. Orthostatic hypotension: II. Clinical diagnosis, testing and treatment. Arch Intern Med 1984;144:1037-1041.
- Pittner H, Stormann H, Enzenhofer R. Pharmacodynamic actions of midodrine, a new alpha-adrenergic stimulating agent, and its main metabolite, ST 1059. Arzneimittelforschung 1976;26:2145-2154.
Cited by
Sorted by citations
Items 201–300 of 330
Midodrine, Adrenergic Agonists and Antagonists
Gilden, J. L. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-386525-0.00130-x · Cited by 7
Diagnosis and Management of Vasovagal Syncope and Dysautonomia
Sealey, B., & Lui, K. (2004) · AACN Clinical Issues Advanced Practice in Acute & Critical Care · doi:10.1097/00044067-200407000-00012 · Cited by 7
Midodrine administration during critical illness: fixed-dose or titrate to response?
Riker, R. R., & Gagnon, D. J. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06321-x · Cited by 7
Approach to Cardiovascular Autonomic Dysfunction in Patients with Synucleinopathies
Lenka, A., & Beach, P. A. (2025) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.70268 · Cited by 6
Is Technology for Orthostatic Hypotension Ready for Primetime?
Sarafis, Z. K., Monga, A., Phillips, A. A., & Krassioukov, A. V. (2018) · PM&R · doi:10.1016/j.pmrj.2018.04.011 · Cited by 6
Amjad, F., & Beinart, S. C. (2021) · Neurology and Therapy · doi:10.1007/s40120-021-00270-3 · Cited by 6
Derrey, S., Maltête, D., Ahtoy, P., Fregey, P., & Proust, F. (2009) · Neurochirurgie · doi:10.1016/j.neuchi.2009.05.002 · Cited by 6
Freeman, R. L., & Kaufmann, H. (2007) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/01.con.0000299966.05395.6c · Cited by 6
Self-citationClinical Spectrum and Pathological Features of Multiple System Atrophy
Colosimo, C., Geser, F., & Wenning, G. K. (2005) · Elsevier eBooks · doi:10.1016/b978-012088382-0/50049-9 · Cited by 6
Orthostatic Hypotension and Supine Hypertension in the Patient with Autonomic Failure
Lamarre-Cliché, M. (2014) · Canadian Journal of General Internal Medicine · doi:10.19144/1911-1606.9.3.2 · Cited by 6
Alseoudy, M. M., Nasr, M. O., & Abdelsalam, T. A. A. (2022) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006173 · Cited by 5
Disorders of the Autonomic Nervous System
Kaufmann, H., & Biaggioni, I. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-6231-8.10063-7 · Cited by 5
Self-citationJourdan, G., Verwaerde, P., Pathak, A., Tran, M. A., Montastruc, J., & Sénard, J. (2006) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2006.00450.x · Cited by 5
Orthostatic Hypotension in Parkinson's Disease
Perez‐Lloret, S., Rey, M. V., Traon, A. P., & Rascol, O. (2013) · Neurodegenerative Disease Management · doi:10.2217/nmt.13.30 · Cited by 5
Zochodne, D. W. (2000) · Current Treatment Options in Neurology · doi:10.1007/s11940-000-0021-2 · Cited by 5
Klinik und Therapie der Multisystematrophie
Geser, F., & Wenning, G. K. (2004) · Journal für Kardiologie (Krause & Pachernegg GmbH) · Cited by 5
Treatment of Diabetic Neuropathy
Pop‐Busui, R., Simmons, Z., & Feldman, E. L. (2010) · Wiley eBooks · doi:10.1002/9780470682807.ch19 · Cited by 5
Treating Lows: Management of Orthostatic Hypotension
Kulkarni, S., Jenkins, D., Dhar, A. S., & Mir, F. A. (2024) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000001597 · Cited by 4
Orthostatic Hypotension—An Approach to Work Up and Management
Brailsford, B., East, E. J., Clayton, J., & Sathyanarayanan, A. (2025) · British Journal of Hospital Medicine · doi:10.12968/hmed.2024.0602 · Cited by 4
Orthostatic hypotension in Parkinson’s disease: therapeutic considerations
Wyant, K. J., & Kotagal, V. (2025) · Therapeutic Advances in Neurological Disorders · doi:10.1177/17562864251363292 · Cited by 4
Manejo de la disfunción autonómica en la enfermedad de Parkinson
Crespo-Burillo, J. A., & Alejos, R. A. (2015) · Revista de Neurología · doi:10.33588/rn.6008.2014341 · Cited by 4
Neurogenic orthostatic hypotension with Parkinson's disease as a cause of syncope: A case report
Li, Y., Wang, M., Liu, X.-L., Ren, Y.-F., & Zhang, W.-B. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i21.6073 · Cited by 4
Treatment and Management of FXTAS
Hall, D. A., Leehey, M. A., Berry‐Kravis, E., & Hagerman, R. J. (2016) · Springer eBooks · doi:10.1007/978-3-319-33898-9_9 · Cited by 4
Methylene Blue, Midodrine, and Pseudoephedrine
Patel, M. V. B., Fuller, L. A., Alexandrov, A. W., & Jones, G. M. (2015) · Critical Care Nursing Quarterly · doi:10.1097/cnq.0000000000000086 · Cited by 4
Neurogenic orthostatic hypotension – management update and role of droxidopa
Sharma, V. K., & Vijayan, J. (2015) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s68439 · Cited by 4
Treatment Strategies and Quality-of-Care Indicators for Patients With Parkinson's Disease
Chen, J. J., Lew, M., & Siderowf, A. D. (2009) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2009.15.s3.1 · Cited by 4
Management of coexistent neurogenic orthostatic hypotension and supine hypertension
Cannom, D. S. (2019) · Journal of Clinical Hypertension · doi:10.1111/jch.13699 · Cited by 4
Autonomic dysfunction and management
Richard B. Dewey Jr., P. K. (2013) · CRC Press eBooks · doi:10.1201/b14361-9 · Cited by 4
Autonomic Dysfunction in Neuromuscular Disorders
Silvestri, N. J., & Gibbons, C. H. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4377-0372-6.00005-0 · Cited by 4
Risk of Orthostatic Intolerance During Re-Exposure to Gravity
Platts, S. H., Stenger, M. B., Lee, S. M. C., Westby, C. M., Phillips, T. R., Arzeno, N. M., Johnston, S. L., & Mulugeta, L. (2015) · NASA Technical Reports Server (NASA) · Cited by 4
Multiple System Atrophy: Clinical, Genetics, and Neuropathology
Schottlaender, L., Sailer, A., Ahmed, Z., Dickson, D. W., Houlden, H., & Ross, O. A. (2017) · Neurodegeneration · doi:10.1002/9781118661895.ch7 · Cited by 4
Riker, R. R., & Gagnon, D. J. (2022) · Journal of Critical Care · doi:10.1016/j.jcrc.2022.153995 · Cited by 4
Management of Orthostatic Hypotension
Moloney, D. J., Youssef, A., & Okamoto, L. E. (2026) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2026.0284 · Cited by 3
The Ongoing Pursuit to Reduce the Burden of IV Vasopressor Infusions
Wieruszewski, P. M., & Lal, A. (2024) · Critical Care Medicine · doi:10.1097/ccm.0000000000006531 · Cited by 3
Puissant, M. M., Armstrong, K., Riker, R. R., Haydar, S. A., Strout, T. D., Smith, K., Seder, D. B., & Gagnon, D. J. (2025) · The Journal of Critical Care Medicine · doi:10.2478/jccm-2025-0007 · Cited by 3
Personalised physiological medicine: Orthostatic hypotension
Owen, C. M., Newton, J. L., & Frith, J. (2022) · Medical Hypotheses · doi:10.1016/j.mehy.2022.110928 · Cited by 3
Sekar, A., Datta, D., Lakha, A., Jena, S. S., Bansal, S., & Sahu, R. N. (2023) · Asian Journal of Neurosurgery · doi:10.1055/s-0043-1769755 · Cited by 3
Amin, S. M., Hasanin, A. M., Mansour, R., Mostafa, M. M. A., Zakaria, D., Arafa, A. S., Yassin, A., & Ziada, H. F. M. (2024) · BMC Anesthesiology · doi:10.1186/s12871-024-02442-8 · Cited by 3
Patologie del sistema nervoso vegetativo
Mandrioli, J., & Cortelli, P. (2009) · Springer eBooks · doi:10.1007/978-88-470-1120-5_37 · Cited by 3
Pharmacological treatments of postural hypotension
Gibbons, C. H., Raj, S. R., Lahrmann, H., & Benatar, M. G. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008269 · Cited by 3
Parkinson’s Disease: Diagnosis, Motor Symptoms and Non-motor Features
Jankovic, J. J. (2013) · doi:10.2217/9781780843391 · Cited by 4
Andréelli, F., Plotton, I., Thivolet, C. H., & Riou, J. P. (1999) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.1999.00051.x · Cited by 3
Cardiovascular System in Space
Ramsdell, C. D., & Cohen, R. J. (2003) · Encyclopedia of Space Science and Technology · doi:10.1002/0471263869.sst074 · Cited by 2
Cammerman, A. C., Haslam, D. W., Currigan, D. A., & Lennon, M. J. (2025) · Anaesthesia and Intensive Care · doi:10.1177/0310057x241290536 · Cited by 2
Pharmacological Interventions for Orthostatic Hypotension: A Systematic Review
Verma, A., Saraya, E., Haque, M. S., Senaratne, M., Khan, S., Kasagga, A., & Malasevskaia, I. A. (2025) · Cureus · doi:10.7759/cureus.89911 · Cited by 2
Hypotension orthostatique : physiopathologie, diagnostic et traitements
Sénard, J. (2012) · EMC - Cardiologie · doi:10.1016/s1166-4568(12)45138-5 · Cited by 2
Autonomic Dysfunction in Neuromuscular Disorders
Gibbons, C. H., & Silvestri, N. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-71317-7.00005-6 · Cited by 3
Adjuvante Therapie nach Rückenmarkverletzung
Maier, D. D. (2010) · Trauma und Berufskrankheit · doi:10.1007/s10039-010-1665-0 · Cited by 2
Atypical parkinsonism, parkinsonism-plus syndromes, and secondary parkinsonian disorders
Fahn, S., Jankovic, J. J., & Hallett, M. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-2369-4.00009-3 · Cited by 2
Treatment of Neurogenic Orthostatic Hypotension
Byun, J., & Kim, S. B. (2017) · Research in Vestibular Science · doi:10.21790/rvs.2017.16.3.73 · Cited by 2
Guaraldi, P., & Buonaura, G. C. (2023) · Springer eBooks · doi:10.1007/978-3-031-43036-7_2 · Cited by 2
Treatment of fatigue in palliative care
Boohene, J. (2009) · CRC Press eBooks · doi:10.1201/b13272-80 · Cited by 2
Management of Autonomic Failure
Low, P. A., & Singer, W. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50122-8 · Cited by 2
Self-citationLahrmann, H., Cortelli, P., Hilz, M. J., Mathias, C. J., Struhal, W., & Tassinari, M. (2006) · doi:10.1002/9780470753279.ch36 · Cited by 2
Santer, P., & Eikermann, M. (2021) · Intensive Care Medicine · doi:10.1007/s00134-020-06333-7 · Cited by 2
Randomised-control trials do not support midodrine as an intravenous vasopressor weaning strategy
Costa‐Pinto, R., & Bellomo, R. (2022) · Journal of Critical Care · doi:10.1016/j.jcrc.2022.153996 · Cited by 2
Biaggioni, I., & Kaufmann, H. (2014) · Encyclopedia of the Neurological Sciences · doi:10.1016/b978-0-12-385157-4.00507-8 · Cited by 2
Self-citationOrthostatic Hypotension and Vasovagal Syncope
Shaw, B. H., Ng, J., & Raj, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809657-4.99798-9 · Cited by 2
Trastornos cardiovasculares en la enfermedad de Parkinson
Moro, R. S., & García, B. C. (2010) · Revista de Neurología · doi:10.33588/rn.50s02.2009741 · Cited by 2
Dounia, J., Kamal, H., Selmaoui, M., Meryem, H., Habbal, R., Abdenasser, D., & Azzouzi, L. (2024) · Journal of Medical Case Reports · doi:10.1186/s13256-024-04346-0 · Cited by 1
Enteral Midodrine for Intravenous Vasopressor Weaning in Acute Traumatic Spinal Cord Injury Patients
Chau, T., Colosimo, C. M., Delic, J. J., Igneri, L. A., Solomon, D. M., & Wang, J.-L. (2024) · Hospital Pharmacy · doi:10.1177/00185787241306278 · Cited by 1
Small Fiber Neuropathy in Sarcoidosis
Voortman, M., Raasing, L. R. M., Burggraaff, J., Wieske, L., & Veltkamp, M. (2025) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/a-2716-1691 · Cited by 1
L-Dops and the Treatment of Neurogenic Orthostatic Hypotension
Vichayanrat, E., Low, D. A., Asahina, M., Owens, A. P., Iodice, V., Galizia, G., & Mathias, C. J. (2013) · Future Neurology · doi:10.2217/fnl.13.28 · Cited by 1
Klinik und Therapie der Multisystem- atrophie und progressiven supra- nukleären Paralyse
Geser, F., & Wenning, G. K. (2005) · Cited by 1
OBSOLETE: Orthostatic Hypotension and Vasovagal Syncope
Raj, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99798-8 · Cited by 1
2018 KHRS guideline for the evaluation and management of syncope-Part 1
Park, J., Cha, M.-J., Kim, D. H., Kim, Y. R., Mun, H. S., Bae, E. J., Seo, D. W., Song, M. K., Ahn, J., Yoon, H. D., et al. (2018) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2018.009 · Cited by 1
Orthostatic hypotension. Part 2: diagnosis and treatment
Golovina, G., Николаевна, Ж. О., Zargaryan, K. A., Kravchenko, O., & Tripolskaya, N. E. (2020) · Innovative medicine of Kuban · doi:10.35401/2500-0268-2020-19-3-77-85 · Cited by 2
2018 KHRS guideline for the evaluation and management of syncope-Part 2
Kim, Y. R., Chun, K. J., Kim, J. S., Mun, H. S., Park, J., Seo, D. W., Song, M. K., Ahn, J. H., Yoon, H. J., Lee, D. I., et al. (2018) · International Journal of Arrhythmia · doi:10.18501/arrhythmia.2018.010 · Cited by 1
Gierthmühlen, J., & Baron, R. (2020) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/a-1165-7184 · Cited by 1
Palma, J., & Kaufmann, H. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00038-7 · Cited by 1
Self-citationDiabetes and the Autonomic Nervous Systems
Hohler, A. D., Vaou, O., & Ho, D. (2023) · Contemporary cardiology · doi:10.1007/978-3-031-13177-6_19 · Cited by 1
Xie, T. (2025) · CONTINUUM Lifelong Learning in Neurology · doi:10.1212/cont.0000000000001598 · Cited by 2
Therapeutic Advances in the Management of Orthostatic Hypotension
Patel, K., Kiszko, K., & Torbati, A. (2018) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000661 · Cited by 1
Synkopenmanagement in der Praxis
Oebel, S., & Hindricks, G. (2018) · Herz · doi:10.1007/s00059-018-4757-4 · Cited by 1
Clinical Trials for Orthostatic Hypotension in Parkinson’s Disease and Other Synucleinopathies
Palma, J., & Kaufmann, H. (2020) · Neuromethods · doi:10.1007/978-1-0716-0912-5_13 · Cited by 1
Self-citationManagement/Treatment of Lambert-Eaton Myasthenic Syndrome
Harada, Y., & Guptill, J. T. (2021) · Current Treatment Options in Neurology · doi:10.1007/s11940-021-00690-4 · Cited by 1
Pharmacotherapy in Spinal Cord Injuries
Ko, H.-Y., & Huh, S. (2021) · Springer eBooks · doi:10.1007/978-981-16-3679-0_5 · Cited by 1
Yang, S., & ZIMETBAUM, P. J. (2020) · Springer eBooks · doi:10.1007/978-3-030-47868-1_26 · Cited by 1
Adrenergic Agonists and Antagonists in Autonomic Failure
Freeman, R. L. (2004) · Elsevier eBooks · doi:10.1016/b978-012589762-4/50115-8 · Cited by 1
Autonomic dysfunction in Parkinson’s disease
Norcliffe‐Kaufmann, L., & Kaufmann, H. (2013) · doi:10.2217/ebo.13.162 · Cited by 1
Self-citationColman, N., Wieling, W., & Freeman, R. (2003) · Elsevier eBooks · doi:10.1016/b978-012125831-3/50300-2 · Cited by 1
Kulkarni, S., Jenkins, D., Pavey, H., Phillips, V., & Mir, F. A. (2022) · doi:10.22541/au.166733104.47069040/v1 · Cited by 1
Chapter 3 Multiple System Atrophy
Geser, F., Globas, C., Schöls, L. J., & Wenning, G. K. (2007) · Blue books of neurology · doi:10.1016/s1877-184x(09)70077-2
Типы ортостатических реакций артериального давления и их клиническое значение
Черная, Ю. А. (2010) · Electronic Kharkiv National University Institutional Repository (Kharkiv National University)
Autonomic Dysfunction and Syncope
Das, R. R. (2014) · Wiley eBooks · doi:10.1002/9781118730676.ch14
Hipotensión ortostática: mecanismos, etiología y principios de tratamiento
Blétry, O., & Marroun, I. (2014) · EMC - Tratado de Medicina · doi:10.1016/s1636-5410(14)67519-x
Ipotensione ortostatica: meccanismi, eziologie e principi di trattamento
Blétry, O., & Marroun, I. (2014) · EMC - AKOS - Trattato di Medicina · doi:10.1016/s1634-7358(14)67533-1
Beleslin, B., Deljanin, M., Kanjuh, V., Parapid, B. J., Giga, V. L., Prostran, M. S., Angelkov, L., Balinovac, J., Bikicki, M., Ambrosio, G., et al. (2013)
Postural Hypotension and Anhidrosis
Low, P. A. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-311-0_25
Self-citationLes marqueurs biologiques de l'atrophie multisystématisée
Laurens, B. (2014) · HAL
Smith, N. D. (2013) · Journal of Pharmacy Technology · doi:10.1177/875512251302900105
Midodrine and Other Sympathomimetics
Gilden, J. L. (2004) · Elsevier eBooks · doi:10.1016/b978-012589762-4/50113-4
Evidenzbasierte Therapie der neurogenen orthostatischen Hypotonie
Eschlböck, S., Fanciulli, A., & Wenning, G. K. (2016) · InFo Neurologie + Psychiatrie · doi:10.1007/s15005-016-1585-z
The Diagnosis and Management of Cardiovascular Autonomic Dysfunction and Disease
Hagen, E. M., & Navarro‐Otano, J. (2017) · Springer eBooks · doi:10.1007/978-3-319-05143-7_3
Use caution when treating supine hypertension in patients with neurogenic orthostatic hypotension
Writers, A. M. (2017) · Drugs & Therapy Perspectives · doi:10.1007/s40267-017-0460-4
A 68-year-old female with probable multiple system atrophy
Kidnie, R. T., Mowrey, J., Mantilla, D. R., Nicklas, R. D., Rangarajan, R., & Wenning, G. K. (2017) · International Journal of Case Reports and Images · doi:10.5348/ijcri-2017127-cr-10866
Pure Autonomic Failure: Diagnosis, Differential Diagnosis, and Natural History
Jones, P. K., & Freeman, R. L. (2018) · Contemporary Endocrinology · doi:10.1007/978-3-319-77048-2_12
Treatment of Cardiovascular Autonomic Failure
Freeman, R. L. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9491-7.50123-x
Inotropic and Vasopressor Agents
Frishman, W. H., Cheng-Lai, A., & Chen, J. Y. (2000) · doi:10.1007/978-1-4615-6767-7_11
Metadata
- Authors
- Wright, R. A., Kaufmann, H. C., Perera, R., Opfer-Gehrking, T. L., McElligott, M. A., Sheng, K. N., & Low, P. A.
- Affiliations
- Mayo Clinic (US)
- Venue
- Neurology
- Published
- 1998-07
- Volume
- 51
- Issue
- 1
- Pages
- 120-124
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2048764982
- Cited by
- 331
- References
- 5
- Citations by year
- 2026: 8 · 2025: 14 · 2024: 8 · 2023: 11 · 2022: 12 · 2021: 14 · 2020: 23 · 2019: 8 · 2018: 16 · 2017: 24 · 2016: 9 · 2015: 16 · 2014: 24 · 2013: 22 · 2012: 5
- FWCI
- 5.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mayo Foundation for Medical Education and Research
- National Institutes of Health (1p01ns032352-01a1)
- National Institute of Neurological Disorders and Stroke (P01 NS 32352)
- National Center for Research Resources (5MO RR00071)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- midodrine, neurogenic orthostatic hypotension, alpha-adrenergic agonists, dose-response relationship, pharmacokinetics, blood pressure, symptom improvement
- MeSH terms
- Adrenergic alpha-Agonists, Adult, Aged, Autonomic Nervous System Diseases, Dose-Response Relationship, Drug, Double-Blind Method, Female, Humans, Hypotension, Orthostatic, Male, Middle Aged, Midodrine, Cross-Over Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
