Medial temporal lobe atrophy on MRI in dementia with Lewy bodies
Open accessAbstract
Objective To investigate whether medial temporal lobe atrophy (MTA) on MRI is less frequent in dementia with Lewy bodies (DLB) compared with AD and vascular dementia (VaD), and to determine the diagnostic utility of MTA in the differential diagnosis of dementia. Method Coronal T1-weighted 1.0-T MR images were acquired in patients with DLB (consensus criteria; n = 26; mean age, 75.9 years), AD (National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association; n = 28; mean age, 77.4 years), VaD (National Institute of Neurological Disorders and Stroke-Association Internationale pour la Recherche et l'Enseignement en Neurosciences; n = 24; mean age, 76.9 years), and normal control subjects (n = 26; mean age, 76.2 years). Cognitive function was assessed using the Cambridge Cognitive Examination (CAMCOG), and MTA was rated visually using a standardized scale. Results MTA was more frequent and severe in all dementia groups compared with control subjects (AD, 100%; VaD, 88%; DLB, 62%; control subjects, 4%; p Conclusion Patients with DLB have significantly greater MTA than control subjects but significantly less than those with AD. The authors confirmed that the presence of MTA is useful in detecting AD but less useful in differentiating between dementias. However, in the differentiation of DLB from AD and VaD, the absence of MTA is highly suggestive of a diagnosis of DLB.
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MTA may also be present in other types of dementia and absence of MTA does not exclude the diagnosis of AD especially in the early stage.
“However, MTA may also be present in other types of dementia (Tam et al., 2005; Barber et al., 1999) and absence of MTA does not exclude the diagnosis of AD especially in the early stage.”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Barber et al., 1999
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- Authors
- Barber, R., Gholkar, A., Scheltens, P., Ballard, C., McKeith, I. G., & O’Brien, J. T.
- Affiliations
- Vrije Universiteit Amsterdam (NL)
- From the Institute for the Health of the Elderly (Drs. BarberMcKeith, and O’Brien), MRC Neurochemical Pathology Unit (Dr. Ballard), and Department of Neuroradiology (Dr. Gholkar), Newcastle General Hospital, Newcastle upon Tyne, U.K; and the Department of Neurology (Dr. Scheltens), Academisch Ziekenhuis VU, Amsterdam, the Netherlands.
- Venue
- Neurology
- Published
- 1999-04
- Volume
- 52
- Issue
- 6
- Pages
- 1153-1153
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2053071049
- Cited by
- 210
- References
- 1
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 5 · 2017: 5 · 2016: 8 · 2015: 10 · 2014: 12 · 2013: 3 · 2012: 9
- FWCI
- 6.80
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Keywords
- dementia with Lewy bodies, medial temporal lobe atrophy, Alzheimer's disease, vascular dementia, differential diagnosis of dementia, memory impairment, sensitivity and specificity
- MeSH terms
- Aged, Aged, 80 and over, Atrophy, Brain, Dementia, Humans, Magnetic Resonance Imaging, Temporal Lobe, Lewy Bodies
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