[ 11 C] (R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen’s encephalitis
Abstract
This study was designed to explore the feasibility of PET using [11C](R)-PK11195 as an in vivo marker of activated microglia/brain macrophages for the assessment of neuroinflammation in Rasmussen's encephalitis (RE). [11C](R)-PK11195 PET was carried out in four normal subjects, two patients with histologically confirmed RE, and three patients with clinically stable hippocampal sclerosis and low seizure frequency. Binding potential maps showing specific binding of [11C](R)-PK11195 were generated for each subject. Regional binding potential values were calculated for anatomically defined regions of interest after coregistration to and spatial transformation into the subjects' own MRI. In one patient with RE who underwent hemispherectomy, the resected, paraffin-embedded brain tissue was stained with an antibody (CR3/43) that labels activated human microglia. Whereas specific binding of [11C](R)-PK11195 in clinically stable hippocampal sclerosis was similar to that in normal brain, patients with RE showed a focal and diffuse increase in binding throughout the affected hemisphere. In RE, [11C](R)-PK11195 PET can reveal in vivo the characteristic, unilateral pattern known from postmortem neuropathologic study. PET imaging of activated microglia/brain macrophages offers a tool for investigation of a range of brain diseases where neuroinflammation is a component and in which conventional MRI does not unequivocally indicate an inflammatory tissue reaction. [11C](R)-PK11195 PET may hel…
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It is generally accepted that microglia and macrophages are the primary cell types exhibiting an increased number of TSPO binding sites in human pathologies, and that astrocytes are not significant contributors to increased TSPO binding sites.
“It is generally accepted that microglia and macrophages are the primary cell types exhibiting an increased number of TSPO binding sites in human pathologies, and that astrocytes are not significant contributors to increased TSPO binding sites [44;45].”
From Expression of the translocator protein of 18 kDa by microglia, macrophages and astrocytes based on immunohistochemical localization in abnormal human brain (2009) · cites this paper as [45]
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- Authors
- Banati, R. B., Goerres, G. W., Myers, R., Gunn, R. N., Turkheimer, F. E., Kreutzberg, G. W., Brooks, D. J., Jones, T., & Duncan, J. S.
- Affiliations
- Hammersmith Hospital (GB)
- Venue
- Neurology
- Published
- 1999-12
- Volume
- 53
- Issue
- 9
- Pages
- 2199-2199
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2043878814
- Cited by
- 224
- References
- 12
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 15 · 2013: 8 · 2012: 8
- FWCI
- 5.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Keywords
- Rasmussen encephalitis, [11C](R)-PK11195, microglial activation, neuroinflammation, brain macrophages, positron emission tomography, binding potential, hippocampal sclerosis, hemispherectomy, biopsy site selection
- MeSH terms
- Adolescent, Adult, Brain, Brain Mapping, Diagnosis, Differential, Encephalitis, Epilepsies, Partial, Feasibility Studies, Female, Hippocampus, Humans, Isoquinolines, Macrophages, Male, Middle Aged, Sclerosis, Tomography, Emission-Computed, Biomarkers, Epilepsy, Complex Partial, Microglia
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