Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia
Open accessAbstract
The authors determined rates of brain atrophy, as assessed by the boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20). Mean % +/- SD atrophy rates per year were as follows: DLB, 1.4 +/- 1.1; AD, 2.0 +/- 0.9; VaD, 1.9 +/- 1.1; and controls, 0.5 +/- 0.7. Dementia subjects had higher rates than controls (p < 0.001), but there were no significant differences between the three dementia groups. The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia.
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One study found people with AD had an atrophy rate of 2.0% per year compared to 1.9% in VaD and 1.4% in DLB.
“One study found people with AD had an atrophy rate of 2.0% per year compared to 1.9% in VaD and 1.4% in DLB [43].”
From The use of neuroimaging techniques in the early and differential diagnosis of dementia (2023) · cites this paper as [43]
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References 10 · Cited by 215
- Authors
- O’Brien, J. T., Paling, S., Barber, R., Williams, E. D., Ballard, C., McKeith, I. G., Gholkar, A., Crum, W. R., Rossor, M. N., & Fox, N. C.
- Affiliations
- From the Institute for the Health of the Elderly (Drs. O’Brien, Paling, Barber, Williams, Ballard, McKeith, and Gholkar), Newcastle General Hospital, Newcastle upon Tyne; and the Dementia Research Group (Drs. Crum, Rossor, and Fox), Institute of Neurology, University College, London, United Kingdom.
- UCL Queen Square Institute of Neurology (GB)
- Venue
- Neurology
- Published
- 2001-05-22
- Volume
- 56
- Issue
- 10
- Pages
- 1386-1388
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2004500341
- Cited by
- 215
- References
- 10
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 4 · 2018: 7 · 2017: 9 · 2016: 5 · 2015: 6 · 2014: 9 · 2013: 9 · 2012: 7
- FWCI
- 11.07
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Keywords
- brain atrophy, dementia with Lewy bodies, Alzheimer's disease, vascular dementia, serial MRI, atrophy rate, cognitive impairment severity, early diagnosis of dementia
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Dementia, Vascular, Disease Progression, Lewy Body Disease
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