The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy [RETRACTED]
Abstract
BACKGROUND: Bone loss and hypovitaminosis D are reported in patients taking antiepileptic drugs, but little is known about changes in bone and calcium metabolism from valproic acid (VPA). OBJECTIVE: To assess the relationship of VPA to bone mass and calcium metabolism in 40 adults with epilepsy on long-term VPA monotherapy, 40 age- and sex-matched epileptic patients taking phenytoin (PHT), and 40 healthy control subjects. Bone mineral density (BMD) of the second metacarpal was determined as T- and Z-scores. RESULTS: BMD reduction from control values was 14% (12% in men, 16% in women) with VPA and 13% (12% in men, 15% in women) with PHT. Among patients on VPA, nine (23%) had T-scores below -2.5 SD, suggesting osteoporosis; 15 (37%) had T-scores between -1 and -2.5 SD, suggesting osteopenia. Serum concentrations of calcium were significantly higher with VPA than in PHT or control groups. Serum concentrations of bone Gla protein (a bone formation marker) and pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (ICTP; a bone resorption marker) associated with either drug significantly exceeded control values. Z-scores for BMD in the VPA group correlated negatively with calcium and ICTP. High ICTP correlated positively with ionized calcium, implying that increased bone resorption caused the latter. CONCLUSION: Long-term VPA monotherapy can increase bone resorption, leading to decreased BMD.
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Effect of carbamazepine and valproate on bone mineral density
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Effect of antiepileptic drugs on bone density in ambulatory patients
Farhat, G., Yamout, B., Mikati, M. A., Demirjian, S., Sawaya, R., & El-Hajj Fuleihan, G. (2002) · Neurology · doi:10.1212/wnl.58.9.1348 · Cited by 358
Epidemiological and medical aspects of epilepsy in the elderly
Cloyd, J., Hauser, W., Towne, A., Ramsay, R., Mattson, R., Gilliam, F., & Walczak, T. (2006) · Epilepsy Research · doi:10.1016/j.eplepsyres.2005.07.016 · Cited by 262
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Emmett, M. J., & Lazar, M. A. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0076-0 · Cited by 202
Bone mineral density in subjects using central nervous system-active medications
Kinjo, M., Setoguchi, S., Schneeweiss, S., & Solomon, D. H. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.07.033 · Cited by 191
Behera, J., Kelly, K. E., Voor, M. J., Metreveli, N., Tyagi, S. C., & Tyagi, N. (2018) · Scientific Reports · doi:10.1038/s41598-018-33149-9 · Cited by 59
Metadata
- Authors
- Sato, Y., Kondo, I., Ishida, S., Motooka, H., Takayama, K., Tomita, Y., Maeda, H., & Satoh, K.
- Venue
- Neurology
- Published
- 2001-08-14
- Volume
- 57
- Issue
- 3
- Pages
- 445-449
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W2068014643
- Cited by
- 274
- References
- 11
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- closed
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- Sato, Y., Kondo, I., Ishida, S., Motooka, H., Takayama, K., Tomita, Y., Maeda, H., & Satoh, K. (2001). Decreased bone mass and increased bone turnover with valproate therapy in adults with epilepsy [RETRACTED]. Neurology. https://doi.org/10.1212/wnl.57.3.445
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