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Spontaneous CSF leaks: Underlying disorder of connective tissue
Abstract
Of 58 consecutive patients with spontaneous CSF leaks, nine exhibited features of connective tissue disorder. One had Marfan's syndrome. Five additional patients had hyperflexible joints, of whom four had arachnodactyly, four were tall and slender, two had hyperextensible skin, and one had a strong family history of abdominal aorta aneurysms. Retinal detachment at a young age was noted in two. One patient had bilateral carotid dissections. A dural weakness may predispose patients to spontaneous CSF leak.
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“Individuals with EDS have an increased risk of spontaneous cerebrospinal fl uid leaks, which in turn can contribute to worsening of headaches in positions of upright posture (Mokri et al., 2002).”
From Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome (2018) · cites this paper as Mokri et al., 2002
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Metadata
- Authors
- Mokri, B., Maher, C. O., & Sencakova, D.
- Affiliations
- Mayo Clinic (US)
- ORCID
- Maher, Cormac O.
- Venue
- Neurology
- Published
- 2002-03-12
- Volume
- 58
- Issue
- 5
- Pages
- 814-816
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- OpenAlex
- W1991939755
- Cited by
- 207
- References
- 10
- Citations by year
- 2026: 5 · 2025: 4 · 2024: 9 · 2023: 7 · 2022: 7 · 2021: 11 · 2020: 8 · 2019: 11 · 2018: 5 · 2017: 7 · 2016: 10 · 2015: 7 · 2014: 11 · 2013: 9 · 2012: 9
- FWCI
- 8.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Neurosurgical Procedures and Complications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
- Health Sciences › Medicine › Clinical Neurology › Spinal Dysraphism and Malformations
- Keywords
- spontaneous cerebrospinal fluid leak, connective tissue diseases, Marfan syndrome, arachnodactyly, abdominal aortic aneurysm, retinal detachment, carotid artery dissection
- MeSH terms
- Adult, Cerebrospinal Fluid, Child, Connective Tissue Diseases, Female, Humans, Joint Instability, Male, Meninges, Middle Aged, Cerebrospinal Fluid Pressure, Intracranial Hypotension, Carotid Artery, Internal, Dissection
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