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Effects of Oral Caffeine on Postdural Puncture Headache: A Double-Blind, Placebo-Controlled Trial
Abstract
Forty postpartum patients with postdural puncture headache (PDPH) were randomly assigned to receive oral caffeine (300 mg) or a placebo. Intensity of headache, quantitated using a visual analogue pain scale (VAS), was assessed immediately before drug administration and 4 and 24 h later. Relief of PDPH measured as delta VAS (initial VAS - VAS at 4 h) was significantly better in the caffeine than in the placebo group (P = 0.014). Six patients (30%) whose PDPH was relieved by caffeine at 4 h had recurrence of symptoms the following day. Our study demonstrates that caffeine administered orally provides relief, albeit if sometimes transient, from PDPH with minimal side effects.
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Citations
Cited by
Post-dural puncture headache: pathogenesis, prevention and treatment
Turnbull, D. K., & Shepherd, D. B. (2003) · British Journal of Anaesthesia · doi:10.1093/bja/aeg231 · Cited by 851
COMPLICATIONS OF LUMBAR PUNCTURE
Evans, R. W. (1998) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70368-6 · Cited by 285
Diener, H., Pfaffenrath, V, Pageler, L., Peil, H., & Aicher, B. (2005) · Cephalalgia · doi:10.1111/j.1468-2982.2005.00948.x · Cited by 223
Metadata
- Authors
- Camann, W. R., Murray, R. S., Mushlin, P. S., & Lambert, D. H.
- Venue
- Anesthesia & Analgesia
- Published
- 1990-02
- Volume
- 70
- Issue
- 2
- Pages
- 181???184
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2078120465
- Cited by
- 205
- References
- 0
- FWCI
- 2.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Effects of Oral Caffeine on Postdural Puncture Headache: A Double-Blind, Placebo-Controlled Trial. https://app.cochat.ai/papers/10.1213/00000539-199002000-00009
- The paper
- Camann, W. R., Murray, R. S., Mushlin, P. S., & Lambert, D. H. (1990). Effects of Oral Caffeine on Postdural Puncture Headache: A Double-Blind, Placebo-Controlled Trial. Anesthesia & Analgesia. https://doi.org/10.1213/00000539-199002000-00009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
