The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Multimodal Analgesia with Gabapentin and Local Anesthetics Prevents Acute and Chronic Pain After Breast Surgery for Cancer
Abstract
In Brief We evaluated the effect of multimodal analgesia on acute and chronic pain after breast surgery for cancer. Fifty patients scheduled for breast cancer surgery were blindly randomized to receive gabapentin, eutectic mixture of local anesthetics cream, and ropivacaine in the wound or three placebos. Pain (visual analog scale) and analgesics were recorded in the postanesthesia care unit (PACU) 3, 6, and 9 h and 8 days after surgery. Three and 6 mo later, patients were assessed for chronic pain. The treatment group consumed less paracetamol in the PACU (469 versus 991 mg; P < 0.002) and less Lonalgal® (1.0 versus 4.4 tablets; P = 0.003) than the controls, exhibited lower visual analog scale scores at rest in the PACU (P = 0.001) and on postoperative Days 1, 3, and 5 (P = 0.040, P = 0.015, and P = 0.045, respectively), and after movement in the PACU (P = 0.001) and on postoperative Days 2, 4, and 8 (P = 0.028, P = 0.007, and P = 0.032, respectively). Three and 6 mo after surgery, 18 of 22 (82%) and 12 of 21 (57%) of the controls reported chronic pain versus 10 of 22 (45%) and 6 of 20 (30%) in the treatment group (P = 0.028 and P = 0.424, respectively); 5 of 22 and 4 of 21 of the controls required analgesics versus 0 of 22 and 0 of 20 of those treated (P = 0.048 and P = 0.107, respectively). Multimodal analgesia reduced acute and chronic pain after breast surgery for cancer. IMPLICATIONS: Patients subjected to surgery for breast cancer were randomly assigned to receive perioperatively gabapentin, ropivacaine in the operating field, and EMLA around the wound or three placebos. The multimodal analgesia reduced the analgesic requirements significantly and attenuated the acute and chronic pain after surgery when compared with the control group.
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“Fassoulaki et al. randomized 50 patients undergoing breast cancer surgery to receive gabapentin, a eutectic mixture of local anesthetic cream and ropivacaine wound infiltration, or three placebos. They found that pain and analgesic consumption was significantly less 3 months after the surgery in the multimodal analgesia group than the control [33].”
From Chronic postsurgical pain: current evidence for prevention and management (2018) · cites this paper as [33]
Citations
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Self-citationA retrospective cohort study of post mastectomy pain syndrome
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Self-citationEpidural block with mepivacaine before surgery reduces long-term post-thoracotomy pain
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Research works printed but not linked: 2
- Fassoulaki, 2001, Reg Anesth Pain Med, 26, 223
- Sarantopoulos, 2002, Reg Anesth Pain Med, 27, 47
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Persistent postsurgical pain: risk factors and prevention
Kehlet, H., Jensen, T. S., & Woolf, C. J. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68700-x · Cited by 4,086
Poorly controlled postoperative pain: prevalence, consequences, and prevention
Gan, T. J. (2017) · Journal of Pain Research · doi:10.2147/jpr.s144066 · Cited by 1,594
Chronic post-surgical pain: 10 years on
Macrae, W. A. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen099 · Cited by 992
Prevalence of and Factors Associated With Persistent Pain Following Breast Cancer Surgery
Gärtner, R., Jensen, M.-B., Nielsen, J., Ewertz, M., Kroman, N., & Kehlet, H. (2009) · JAMA · doi:10.1001/jama.2009.1568 · Cited by 908
Transition from acute to chronic postsurgical pain: risk factors and protective factors
Katz, J., & Seltzer, Z. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.20 · Cited by 782
Metadata
- Authors
- Fassoulaki, A., Triga, A., Melemeni, A., & Sarantopoulos, C.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- St Savas Hospital (GR)
- Medical College of Wisconsin (US)
- Corresponding author
- Fassoulaki, Argyro
- Melemeni, Aikaterini
- ORCID
- Fassoulaki, Argyro
- Venue
- Anesthesia & Analgesia
- Published
- 2005-11
- Volume
- 101
- Issue
- 5
- Pages
- 1427-1432
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W1991737049
- Cited by
- 255
- References
- 19
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 15 · 2017: 13 · 2016: 11 · 2015: 16 · 2014: 19 · 2013: 27 · 2012: 14
- FWCI
- 13.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anesthesia & Analgesia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Anesthesia and Pain Management
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Stress, Anesthesia, and Immune Response
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Opioid Use
- Keywords
- multimodal analgesia, gabapentin, ropivacaine, EMLA, local anesthetics, breast cancer surgery, postoperative pain, chronic pain, postoperative analgesia, paracetamol consumption, post-anesthesia care unit, perioperative analgesia, wound infiltration, opioid-sparing analgesia, postoperative nausea and vomiting, postoperative delirium
- MeSH terms
- Gabapentin, Acute Disease, Adult, Amines, Analgesia, Anesthetics, Local, Breast Neoplasms, Chronic Disease, Cyclohexanecarboxylic Acids, Double-Blind Method, Female, gamma-Aminobutyric Acid, Humans, Middle Aged, Postoperative Pain
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