The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Does Continuous Peripheral Nerve Block Provide Superior Pain Control to Opioids? A Meta-Analysis
Abstract
Although most randomized clinical trials conclude that the addition of continuous peripheral nerve blockade (CPNB) decreases postoperative pain and opioid-related side effects when compared with opioids, studies have included relatively small numbers of patients and the majority failed to show statistical significance during all time periods for reduced pain or side effects. We identified studies primarily by searching Ovid Medline (1966-May 21, 2004) for terms related to postoperative analgesia with CPNB and opioids. Each article from the final search was reviewed and data were extracted from tables, text, or extrapolated from figures as needed. Nineteen articles, enrolling 603 patients, met all inclusion criteria. Inclusion criteria were a clearly defined anesthetic technique (combined general/regional anesthesia, general anesthesia alone, peripheral nerve block), randomized trial, adult patient population (> or =18 yr old), CPNB (or analgesia) used postoperatively (intrapleural catheters were deemed not to be classified as a peripheral nerve catheter), and opioids administered for postoperative analgesia in groups not receiving peripheral nerve block. Perineural analgesia provided better postoperative analgesia compared with opioids (P < 0.001). This effect was seen for all time periods measured for both mean visual analog scale and maximum visual analog scale at 24 h (P < 0.001), 48 h (P < 0.001), and 72 h (mean visual analog scale only) (P < 0.001) postoperatively. Perineural catheters provided superior analgesia to opioids for all catheter locations and time periods (P < 0.05). Nausea/vomiting, sedation, and pruritus all occurred more commonly with opioid analgesia (P < 0.001). A reduction in opioid use was noted with perineural analgesia (P < 0.001). CPNB analgesia, regardless of catheter location, provided superior postoperative analgesia and fewer opioid-related side effects when compared with opioid analgesia.
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Cites
Bias in meta-analysis detected by a simple, graphical test
Egger, M., Smith, G. D., Schneider, M., & Minder, C. (1997) · BMJ · doi:10.1136/bmj.315.7109.629 · Cited by 56,722
Assessing the quality of reports of randomized clinical trials: Is blinding necessary?
Jadad, A. R., Moore, R. A., Carroll, D., Jenkinson, C., Reynolds, D. J. M., Gavaghan, D. J., & McQuay, H. J. (1996) · Controlled Clinical Trials · doi:10.1016/0197-2456(95)00134-4 · Cited by 17,582
Defining the clinically important difference in pain outcome measures
Farrar, J. T., Portenoy, R. K., Berlin, J. A., Kinman, J. L., & Strom, B. L. (2000) · Pain · doi:10.1016/s0304-3959(00)00339-0 · Cited by 1,071
Capdevila, X., Barthelet, Y., Biboulet, P., Ryckwaert, Y., Rubenovitch, J., & d'Athis, F. (1999) · Anesthesiology · doi:10.1097/00000542-199907000-00006 · Cited by 1,028
Direction and impact of language bias in meta-analyses of controlled trials: empirical study
Jüni, P., Holenstein, F., Sterne, J., Bartlett, C., & Egger, M. (2002) · International Journal of Epidemiology · doi:10.1093/ije/31.1.115 · Cited by 892
Moher, D., Pham, B., Lawson, M., & Klassen, T. (2003) · Health Technology Assessment · doi:10.3310/hta7410 · Cited by 500 · cited 1×
“This may introduce publication bias if only positive findings are published primarily in English language journals (25).”
BackgroundClinically Important Changes in Acute Pain Outcome Measures
Farrar, J. T., Berlin, J. A., & Strom, B. L. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(03)00162-3 · Cited by 459
Cost-effectiveness of Prophylactic Antiemetic Therapy with Ondansetron, Droperidol, or Placebo
Hill, R. P., Lubarsky, D. A., Phillips-Bute, B., Fortney, J. T., Creed, M. R., Glass, P. S. A., & Gan, T. J. (2000) · Anesthesiology · doi:10.1097/00000542-200004000-00012 · Cited by 360
Chelly, J. E., Greger, J., Gebhard, R., Coupe, K., Clyburn, T. A., Buckle, R., & Criswell, A. (2001) · The Journal of Arthroplasty · doi:10.1054/arth.2001.23622 · Cited by 304
Survey of postoperative analgesia following ambulatory surgery
Rawal, N., Hylander, J., NYDAHL, R., Olofsson, I., & Gupta, A. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb04829.x · Cited by 260
Cited by
Chou, R., Gordon, D. B., de Leon-Casasola, O. A., Rosenberg, J. M., Bickler, S., Brennan, T., Carter, T., Cassidy, C. L., Chittenden, E. H., Degenhardt, E., et al. (2016) · The Journal of Pain · doi:10.1016/j.jpain.2015.12.008 · Cited by 3,171
Self-citationSun, E. C., Darnall, B. D., Baker, L. C., & Mackey, S. (2016) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2016.3298 · Cited by 1,078
Hah, J. M., Bateman, B. T., Ratliff, J., Curtin, C., & Sun, E. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002458 · Cited by 728
White, P. F., Kehlet, H., Neal, J. M., Schricker, T., Carr, D. B., & Carli, F. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000263034.96885.e1 · Cited by 485
Kumar, K., Kirksey, M. A., Duong, S., & Wu, C. L. (2017) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000002497 · Cited by 308
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Metadata
- Authors
- Richman, J. M., Liu, S. S., Courpas, G., Wong, R., Rowlingson, A. J., McGready, J., Cohen, S. R., & Wu, C. L.
- Venue
- Anesthesia & Analgesia
- Published
- 2006-01
- Volume
- 102
- Issue
- 1
- Pages
- 248-257
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2152261628
- Cited by
- 687
- References
- 17
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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- Richman, J. M., Liu, S. S., Courpas, G., Wong, R., Rowlingson, A. J., McGready, J., Cohen, S. R., & Wu, C. L. (2006). Does Continuous Peripheral Nerve Block Provide Superior Pain Control to Opioids? A Meta-Analysis. Anesthesia & Analgesia. https://doi.org/10.1213/01.ane.0000181289.09675.7d
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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