Polydatin Inhibits Mitochondrial Dysfunction in the Renal Tubular Epithelial Cells of a Rat Model of Sepsis-Induced Acute Kidney Injury
Abstract
Background Mitochondrial injury is a major cause of sepsis-induced organ failure. Polydatin (PD), a natural polyphenol, demonstrates protective mitochondrial effects in neurons and arteriolar smooth muscle cells during severe shock. In this study, we investigated the effects of PD on renal tubular epithelial cell (RTEC) mitochondria in a rat model of sepsis-induced acute kidney injury. Methods Rats underwent cecal ligation and puncture (CLP) to mimic sepsis-induced acute kidney injury. Rats were randomly divided into sham, CLP + normal saline, CLP + vehicle, and CLP + PD groups. Normal saline, vehicle, and 30 mg/kg PD were administered at 6, 12, and 18 hours after CLP or sham surgery via the tail vein. Mitochondrial morphology, metabolism, and function in RTECs were then assessed. Serum cytokines, renal function, survival, and histologic changes in the kidney were also evaluated. Results CLP increased lipid peroxide content, lysosomal instability, and opening of the mitochondrial permeability transition pore and caused mitochondrial swelling. Moreover, mitochondrial membrane potential (ΔΨm) was decreased and ATP levels reduced after CLP. PD inhibited all the above effects. It also inhibited the inflammatory response, improved renal function, attenuated histologic indicators of kidney damage, and prolonged survival. Conclusions PD protects RTECs against mitochondrial dysfunction and prolongs survival in a rat model of sepsis-induced acute kidney injury. These effects may parti…
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Polydatin and citrate caffeine have demonstrated neuroprotective effects by improving mitochondrial function and reducing inflammation, underscoring the importance of mitochondrial health in SAE therapy.
“Additionally, Polydatin derived from Polygonum cuspidatum (Gao et al. 2015) and citrate caffeine (Hu et al. 2022) have demonstrated neuroprotective effects by improving mitochondrial function and reducing inflammation, underscoring the importance of mitochondrial health in SAE therapy.”
From Transcript and Lipid Profile Alterations in Astrocyte‐Neuron Mitochondrial Transfer Under Lipopolysaccharide Exposure: An In Vitro Study (2025) · cites this paper as Gao et al. 2015
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Lysosomes in iron metabolism, ageing and apoptosis
Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Histochemistry and Cell Biology · doi:10.1007/s00418-008-0394-y · Cited by 302 · see citing works
Lysosomes and oxidative stress in aging and apoptosis
Kurz, T., Terman, A., Gustafsson, B., & Brunk, U. T. (2008) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.01.009 · Cited by 287 · see citing works
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Kan, Y., Wang, H., Lin, H., Li, Y., Pei, S., Cui, Y., Xie, K., Chen, H., & Yu, Y. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70003 · Cited by 8 · see citing works
- Authors
- Gao, Y., Zeng, Z., Li, T., Xu, S., Wang, X., Chen, Z., & Lin, C.
- Affiliations
- Nanfang Hospital (CN)
- Chenzhou First People's Hospital (CN)
- Southern Medical University (CN)
- Liuzhou Maternal and Child Health Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Corresponding author
- Gao, Youguang
- Zeng, Zhenhua
- Chen, Zhongqing
- Venue
- Anesthesia & Analgesia
- Published
- 2015-11
- Volume
- 121
- Issue
- 5
- Pages
- 1251-1260
- ISSN
- 0003-2999 (ISSN-L)
- OpenAlex
- W2284922103
- Cited by
- 57
- References
- 2
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 6 · 2022: 12 · 2021: 10 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 3 · 2016: 5
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anesthesia & Analgesia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Health Sciences › Medicine › Epidemiology › Sepsis Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- polydatin, sepsis-associated acute kidney injury, mitochondrial dysfunction, renal tubular epithelial cells, cecal ligation and puncture, mitochondrial permeability transition pore, mitochondrial swelling, oxidative stress, interleukin-6, inflammation, mitochondrial membrane potential, ATP depletion, lipid peroxidation, polyphenols
- MeSH terms
- Animals, Disease Models, Animal, Drugs, Chinese Herbal, Epithelial Cells, Glucosides, Kidney Tubules, Mitochondria, Stilbenes, Rats, Sprague-Dawley, Sepsis, Rats, Membrane Potential, Mitochondrial, Acute Kidney Injury
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