Time-uniform, nonparametric, nonasymptotic confidence sequences
Open accessAbstract
A confidence sequence is a sequence of confidence intervals that is uniformly valid over an unbounded time horizon. Our work develops confidence sequences whose widths go to zero, with nonasymptotic coverage guarantees under nonparametric conditions. We draw connections between the Cramér–Chernoff method for exponential concentration, the law of the iterated logarithm (LIL) and the sequential probability ratio test—our confidence sequences are time-uniform extensions of the first; provide tight, nonasymptotic characterizations of the second; and generalize the third to nonparametric settings, including sub-Gaussian and Bernstein conditions, self-normalized processes and matrix martingales. We illustrate the generality of our proof techniques by deriving an empirical-Bernstein bound growing at a LIL rate, as well as a novel upper LIL for the maximum eigenvalue of a sum of random matrices. Finally, we apply our methods to covariance matrix estimation and to estimation of sample average treatment effect under the Neyman–Rubin potential outcomes model.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Conditional Ville's inequality justifies acceptance when E_{k,n} ≥ 1/α_k at any inspected stopping time.
“Conditional Ville's inequality justifies acceptance when E k,n ≥ 1/α k at any inspected stopping time (Howard et al., 2021;Waudby-Smith & Ramdas, 2024).”
From SGM: A Statistical Godel Machine for Risk-Controlled Recursive Self-Modification (2025) · cites this paper as Howard et al., 2021
Section 3.2 gives a time-uniform crossing bound for a supermartingale-based quantity at a threshold proportional to 1/α, and the discussion around Lemma 3 says sequential tests remain valid at stopping times. The paper does not state a conditional Ville inequality for E_{k,n} or justify the cited acceptance rule; its explicit testing example describes rejecting a null when a boundary is crossed. The indexed passages provide section labels but no page numbers. (LLM, conf=0.80)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Estimating causal effects of treatments in randomized and nonrandomized studies
Rubin, D. B. (1974) · Journal of Educational Psychology · doi:10.1037/h0037350 · Cited by 9,436 · see citing works
Causal Inference for Statistics, Social, and Biomedical Sciences: An Introduction
Imbens, G. W., & Rubin, D. B. (2015) · doi:10.1017/cbo9781139025751 · Cited by 4,210 · see citing works
Discrete sequential boundaries for clinical trials
GORDON LAN, K. K., & DEMETS, D. L. (1983) · Biometrika · doi:10.1093/biomet/70.3.659 · Cited by 2,310 · see citing works
Flagged first, then by citations
Research works printed but not linked: 52
- ARMITAGE, P., MCPHERSON, C. K. and ROWE, B. C. (1969). Repeated significance tests on accumulating data. J. Roy. Statist. Soc. Ser. A 132 235-244. MR0250405 https://doi.org/10.2307/2343787 · DOI
- AUDIBERT, J.-Y., MUNOS, R. and SZEPESVÁRI, C. (2009). Exploration-exploitation tradeoff using variance estimates in multi-armed bandits. Theoret. Comput. Sci. 410 1876-1902. MR2514714 https://doi.org/10.1016/j.tcs.2009.01.016 · DOI
- AZUMA, K. (1967). Weighted sums of certain dependent random variables. Tohoku Math. J. (2) 19 357-367. MR0221571 https://doi.org/10.2748/tmj/1178243286 · DOI
- BALSUBRAMANI, A. (2014). Sharp finite-time iterated-logarithm martingale concentration. arXiv:1405.2639. · arXiv
- BALSUBRAMANI, A. and RAMDAS, A. (2016). Sequential nonparametric testing with the law of the iterated logarithm. In Proceedings of the Thirty-Second Conference on Uncertainty in Artificial Intelligence. UAI'16 42-51. AUAI Press.
- BERCU, B., DELYON, B. and RIO, E. (2015). Concentration Inequalities for Sums and Mar- tingales. SpringerBriefs in Mathematics. Springer, Cham. MR3363542 https://doi.org/10.1007/ 978-3-319-22099-4 · DOI
- BERMAN, R., PEKELIS, L., SCOTT, A. and VAN DEN BULTE, C. (2018). p-hacking and false discovery in A/B testing. Technical Report No. 3204791. SSRN.
- BOUCHERON, S., LUGOSI, G. and MASSART, P. (2013). Concentration Inequalities: A Nonasymptotic Theory of Independence. Oxford Univ. Press, Oxford. With a foreword by Michel Ledoux. MR3185193 https://doi.org/10.1093/acprof:oso/9780199535255.001.0001 · DOI · Paper page
- CHERNOFF, H. (1952). A measure of asymptotic efficiency for tests of a hypothesis based on the sum of observations. Ann. Math. Stat. 23 493-507. MR0057518 https://doi.org/10.1214/aoms/1177729330 · DOI
- DARLING, D. A. and ROBBINS, H. (1967). Confidence sequences for mean, variance, and median. Proc. Natl. Acad. Sci. USA 58 66-68. MR0215406 https://doi.org/10.1073/pnas.58.1.66 · DOI
- DARLING, D. A. and ROBBINS, H. (1967). Iterated logarithm inequalities. Proc. Natl. Acad. Sci. USA 57 1188-1192. MR0211441 https://doi.org/10.1073/pnas.57.5.1188 · DOI
- DARLING, D. A. and ROBBINS, H. (1968). Some further remarks on inequalities for sample sums. Proc. Natl. Acad. Sci. USA 60 1175-1182. MR0235604 https://doi.org/10.1073/pnas.60.4.1175 · DOI
- DE LA PEÑA, V. H., KLASS, M. J. and LAI, T. L. (2004). Self-normalized processes: Exponential in- equalities, moment bounds and iterated logarithm laws. Ann. Probab. 32 1902-1933. MR2073181 https://doi.org/10.1214/009117904000000397 · DOI
- DE LA PEÑA, V. H., KLASS, M. J. and LAI, T. L. (2007). Pseudo-maximization and self-normalized processes. Probab. Surv. 4 172-192. MR2368950 https://doi.org/10.1214/07-PS119 · DOI
- DE LA PEÑA, V. H., KLASS, M. J. and LAI, T. L. (2009). Theory and applications of multivariate self- normalized processes. Stochastic Process. Appl. 119 4210-4227. MR2565565 https://doi.org/10.1016/ j.spa.2009.10.003 · DOI
- DE LA PEÑA, V. H., LAI, T. L. and SHAO, Q.-M. (2009). Self-Normalized Processes: Limit Theory and Statistical Applications. Probability and Its Applications (New York). Springer, Berlin. MR2488094 https://doi.org/10.1007/978-3-540-85636-8 · DOI
- EFRON, B. (1971). Forcing a sequential experiment to be balanced. Biometrika 58 403-417. MR0312660 https://doi.org/10.1093/biomet/58.3.403 · DOI · Paper page
- GARIVIER, A. (2013). Informational confidence bounds for self-normalized averages and applications. In 2013 IEEE Information Theory Workshop (ITW) 1-5. IEEE.
- GARIVIER, A. and LEONARDI, F. (2011). Context tree selection: A unifying view. Stochastic Process. Appl. 121 2488-2506. MR2832411 https://doi.org/10.1016/j.spa.2011.06.012 · DOI
- GITTENS, A. and TROPP, J. A. (2011). Tail bounds for all eigenvalues of a sum of random matrices. ACM Report 2014-02, Caltech.
- GRÜNWALD, P., DE HEIDE, R. and KOOLEN, W. (2019). Safe testing. arXiv:1906.07801. · arXiv
- HOWARD, S. R., RAMDAS, A., MCAULIFFE, J. and SEKHON, J. (2020). Time-uniform Chernoff bounds via nonnegative supermartingales. Probab. Surv. 17 257-317. MR4100718 https://doi.org/10.1214/ 18-PS321 · DOI
- HOWARD, S. R., RAMDAS, A., MCAULIFFE, J. and SEKHON, J. (2021). Supplement to "Time-uniform, nonparametric, nonasymptotic confidence sequences." https://doi.org/10.1214/20-AOS1991SUPP · DOI
- JAMIESON, K. and JAIN, L. (2018). A bandit approach to multiple testing with false discovery control. In Proceedings of the 32nd International Conference on Neural Information Processing Systems 3664- 3674.
- JAMIESON, K., MALLOY, M., NOWAK, R. and BUBECK, S. (2014). lil' UCB: An optimal exploration algorithm for multi-armed bandits. In Proceedings of the 27th Conference on Learning Theory 35 423-439.
- JAMIESON, K. and NOWAK, R. (2014). Best-arm identification algorithms for multi-armed bandits in the fixed confidence setting. In 48th Annual Conference on Information Sciences and Systems (CISS) 1-6.
- JENNISON, C. and TURNBULL, B. W. (2000). Group Sequential Methods with Applications to Clinical Trials. CRC Press/CRC, Boca Raton, FL. MR1710781
- JOHARI, R., KOOMEN, P., PEKELIS, L. and WALSH, D. (2017). Peeking at A/B tests: Why it matters, and what to do about it. 1517-1525. ACM Press.
- JOHARI, R., PEKELIS, L. and WALSH, D. J. (2015). Always valid inference: Bringing sequential analysis to A/B testing. arXiv preprint arXiv:1512.04922. · arXiv
- JØRGENSEN, B. (1997). The Theory of Dispersion Models. Monographs on Statistics and Applied Proba- bility 76. CRC Press, London. MR1462891
- KAUFMANN, E. and KOOLEN, W. (2018). Mixture martingales revisited with applications to sequential tests and confidence intervals. arXiv:1811.11419. · arXiv
- KOLTCHINSKII, V. and LOUNICI, K. (2017). Concentration inequalities and moment bounds for sample covariance operators. Bernoulli 23 110-133. MR3556768 https://doi.org/10.3150/15-BEJ730 · DOI
- KULLDORFF, M., DAVIS, R. L., KOLCZAK, M., LEWIS, E., LIEU, T. and PLATT, R. (2011). A maximized sequential probability ratio test for drug and vaccine safety surveillance. Sequential Anal. 30 58-78. MR2770706 https://doi.org/10.1080/07474946.2011.539924 · DOI
- LAI, T. L. (1976). Boundary crossing probabilities for sample sums and confidence sequences. Ann. Probab. 4 299-312. MR0405578 https://doi.org/10.1214/aop/1176996135 · DOI
- LORDEN, G. and POLLAK, M. (2005). Nonanticipating estimation applied to sequential analy- sis and changepoint detection. Ann. Statist. 33 1422-1454. MR2195641 https://doi.org/10.1214/ 009053605000000183 · DOI
- MAURER, A. and PONTIL, M. (2009). Empirical Bernstein bounds and sample variance penalization. In Proceedings of the Conference on Learning Theory.
- MCDIARMID, C. (1998). Concentration. In Probabilistic Methods for Algorithmic Discrete Mathe- matics. Algorithms Combin. 16 195-248. Springer, Berlin. MR1678578 https://doi.org/10.1007/ 978-3-662-12788-9_6 · DOI
- ROBBINS, H. (1970). Statistical methods related to the law of the iterated logarithm. Ann. Math. Stat. 41 1397-1409. MR0277063 https://doi.org/10.1214/aoms/1177696786 · DOI
- ROBBINS, H. and SIEGMUND, D. (1969). Probability distributions related to the law of the iterated loga- rithm. Proc. Natl. Acad. Sci. USA 62 11-13. MR0242228 https://doi.org/10.1073/pnas.62.1.11 · DOI
- ROBBINS, H. and SIEGMUND, D. (1970). Boundary crossing probabilities for the Wiener process and sample sums. Ann. Math. Stat. 41 1410-1429. MR0277059 https://doi.org/10.1214/aoms/1177696787 · DOI
- ROBBINS, H. and SIEGMUND, D. (1972). A class of stopping rules for testing parametric hypotheses. In Proceedings of the Sixth Berkeley Symposium on Mathematical Statistics and Probability (Univ.
- RUDELSON, M. (1999). Random vectors in the isotropic position. J. Funct. Anal. 164 60-72. MR1694526 https://doi.org/10.1006/jfan.1998.3384 · DOI
- SHAFER, G., SHEN, A., VERESHCHAGIN, N. and VOVK, V. (2011). Test martingales, Bayes factors and p-values. Statist. Sci. 26 84-101. MR2849911 https://doi.org/10.1214/10-STS347 · DOI
- SIEGMUND, D. (1978). Estimation following sequential tests. Biometrika 65 341-349. MR0513934 https://doi.org/10.2307/2335213 · DOI
- SIEGMUND, D. (1985). Sequential Analysis: Tests and Confidence Intervals. Springer Series in Statistics. Springer, New York. MR0799155 https://doi.org/10.1007/978-1-4757-1862-1 · DOI
- TROPP, J. A. (2011). Freedman's inequality for matrix martingales. Electron. Commun. Probab. 16 262- 270. MR2802042 https://doi.org/10.1214/ECP.v16-1624 · DOI
- VERSHYNIN, R. (2012). Introduction to the non-asymptotic analysis of random matrices. In Compressed Sensing 210-268. Cambridge Univ. Press, Cambridge. MR2963170
- WALD, A. (1945). Sequential tests of statistical hypotheses. Ann. Math. Stat. 16 117-186. MR0013275 https://doi.org/10.1214/aoms/1177731118 · DOI
- WALD, A. (1947). Sequential Analysis. Wiley, New York. MR0020764
- WHITEHEAD, J. and STRATTON, I. (1983). Group sequential clinical trials with triangular continuation regions. Biometrics 39 227-236. MR0712749 https://doi.org/10.2307/2530822 · DOI
- YANG, F., RAMDAS, A., JAMIESON, K. G. and WAINWRIGHT, M. J. (2017). A framework for Multi- A(rmed)/B(andit) testing with online FDR control. In 31st Conference on Neural Information Pro- cessing Systems.
- ZHAO, S., ZHOU, E., SABHARWAL, A. and ERMON, S. (2016). Adaptive concentration inequalities for sequential decision problems. In 30th Conference on Neural Information Processing Systems.
Cited by
Sorted by citations
Failing Loudly: An Empirical Study of Methods for Detecting Dataset Shift
Rabanser, S., Günnemann, S., & Lipton, Z. C. (2018) · arXiv · doi:10.48550/arxiv.1810.11953 · Cited by 204 · see citing works
SGM: A Statistical Godel Machine for Risk-Controlled Recursive Self-Modification
Wu, X., Yin, S., Kang, Y., Zhang, X., Xu, Q., Chen, Z., & Zhang, W. (2025) · arXiv · doi:10.48550/arxiv.2510.10232
“Online family-wise error control handles potentially unbounded hypothesis sequences (Tian & Ramdas, 2019); confidence sequences and betting methods support optional stopping (Howard et al., 2021; Waudby-Smith & Ramdas, 2024).”
- Authors
- Howard, S. R., Ramdas, A., McAuliffe, J., & Sekhon, J.
- Affiliations
- University of California, Berkeley (US)
- Carnegie Mellon University (US)
- Yale University (US)
- Venue
- The Annals of Statistics
- Publisher
- Institute of Mathematical Statistics
- Published
- 2021-04-01
- Volume
- 49
- Issue
- 2
- Pages
- 1055-1080
- ISSN
- 0090-5364 (ISSN-L)
- 2168-8966
- OpenAlex
- W3030671780
- Cited by
- 190
- References
- 3
- Citations by year
- 2026: 48 · 2025: 28 · 2024: 25 · 2023: 24 · 2022: 15 · 2021: 23 · 2020: 19 · 2019: 5 · 2018: 3
- FWCI
- 15.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Annals of Statistics (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Funders
- National Science Foundation (1916320)
- Office of Naval Research (N00014-15-1-2367, N00014-17-1-2176, N00014-17-1, N00014, N00014-17)
- Topics
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods and Inference
- Physical Sciences › Mathematics › Statistics and Probability › Probability and Statistical Research
- Social Sciences › Decision Sciences › Management Science and Operations Research › Advanced Bandit Algorithms Research
- Keywords
- confidence sequences, nonparametric statistics, law of the iterated logarithm, sequential probability ratio test, sub-Gaussian distributions, covariance matrix estimation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review