Cited by 296Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchTrauma and Emergency Care Studies

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Circulating Catecholamines and Sympathetic Activity after Head Injury

Clifton, Guy L., Ziegler, Michael G., Grossman, Robert G.·1981·Neurosurgery

DOI 10.1227/00006123-198101000-00003

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Abstract

Plasma norepinephrine (NE) and dopamine beta-hydroxylase (DBH) levels were measured during the first 7 days after head injury in 48 patients. Blood pressure, pulse, temperature, and Glasgow coma score (GCS) were recorded at the time of sampling for each patient, and the relationships of these to NE and DBH were examined. In patients with multiple trauma, NE levels were usually elevated, regardless of the GCS. In patients with head injury alone, however, NE was proportional to GCS. Alert patients after a brief loss of consciousness (GCS, 14) had normal NE levels. Those in coma had levels as high as 7 times normal. Blood pressure, pulse, and temperature were found to be elevated proportionally to elevations in plasma NE in patients with head injury. The finding of elevated plasma NE in patients with severe head injury raises the possibility of adverse effects of sympathetic hyperactivity in patients with severe head injury, including hypermetabolism, cardiovascular abnormalities, and direct effects of catecholamines on the damaged central nervous system.

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Background
Isolated Brain Trauma in Cats Triggers Rapid Onset of Hypovolemia
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Background
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Background
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Authors: Clifton, G. L., Ziegler, M. G., & Grossman, R. G.
Affiliations: University of California San Diego (US)
ORCID: Ziegler, Michael G.
Grossman, Robert G.
Venue: Neurosurgery
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1981-01
Volume: 8
Issue: 1
Pages: 10-14
ISSN: 0148-396X (ISSN-L)
DOI: 10.1227/00006123-198101000-00003
OpenAlex: W1988160703
Cited by: 296
References: 0
Citations by year: 2026: 4 · 2025: 3 · 2024: 8 · 2023: 3 · 2022: 2 · 2021: 8 · 2020: 8 · 2019: 6 · 2018: 6 · 2017: 20 · 2016: 16 · 2015: 14 · 2014: 8 · 2013: 2 · 2012: 6
FWCI: 4.44
Type: journal article
Language: en
Open access: closed
Locations: Neurosurgery (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Health Sciences › Medicine › Emergency Medicine › Trauma and Emergency Care Studies
Keywords: traumatic brain injury, norepinephrine, dopamine beta-hydroxylase, circulating catecholamines, sympathetic hyperactivity, Glasgow coma score, coma, polytrauma, blood pressure, pulses, body temperature, hypermetabolism, cardiovascular anomalies
MeSH terms: Blood Pressure, Brain Injuries, Catecholamines, Coma, Dopamine beta-Hydroxylase, Humans, Norepinephrine, Sympathetic Nervous System

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Circulating Catecholamines and Sympathetic Activity after Head Injury

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