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Cited by 158

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Drosophila Regulatory factor X is necessary for ciliated sensory neuron differentiation

Open access
Dubruille, Raphaelle, Laurençon, Anne, Vandaele, Camille, Shishido, Emiko, Coulon-Bublex, Madeleine, Swoboda, Peter, Couble, Pierre, Kernan, Maurice, Durand, Bénédicte·2002·Development

Abstract

Ciliated neurons play an important role in sensory perception in many animals. Modified cilia at dendrite endings serve as sites of sensory signal capture and transduction. We describe Drosophila mutations that affect the transcription factor RFX and genetic rescue experiments that demonstrate its central role in sensory cilium differentiation. Rfxmutant flies show defects in chemosensory and mechanosensory behaviors but have normal phototaxis, consistent with Rfx expression in ciliated sensory neurons and neuronal precursors but not in photoreceptors. The mutant behavioral phenotypes are correlated with abnormal function and structure of neuronal cilia, as shown by the loss of sensory transduction and by defects in ciliary morphology and ultrastructure. These results identify Rfx as an essential regulator of ciliated sensory neuron differentiation inDrosophila.

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Crossref · 10.1242/dev.00148

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Metadata

Authors
Dubruille, R., Laurençon, A., Vandaele, C., Shishido, E., Coulon-Bublex, M., Swoboda, P., Couble, P., Kernan, M., & Durand, B.
Venue
Development
Published
2002-12-01
Volume
129
Issue
23
Pages
5487-5498
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
OpenAlex
W1985719373
Cited by
158
References
3
FWCI
3.34
Type
journal article
Language
en
Open access
bronze

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