The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Nmyc upregulation by sonic hedgehog signaling promotes proliferation in developing cerebellar granule neuron precursors
Abstract
Hedgehog pathway activation is required for expansion of specific neuronal precursor populations during development and is etiologic in the human cerebellar tumor, medulloblastoma. We report that sonic hedgehog (Shh)signaling upregulates expression of the proto-oncogene Nmyc in cultured cerebellar granule neuron precursors (CGNPs) in the absence of new protein synthesis. The temporal-spatial expression pattern of Nmyc,but not other Myc family members, precisely coincides with regions of hedgehog proliferative activity in the developing cerebellum and is observed in medulloblastomas of Patched (Ptch) heterozygous mice. Overexpression of Nmyc promotes cell-autonomous G1 cyclin upregulation and CGNP proliferation independent of Shh signaling. Furthermore,Myc antagonism in vitro significantly decreases proliferative effects of Shh in cultured CGNPs. Together, these findings identify Nmyc as a direct target of the Shh pathway that functions to regulate cell cycle progression in cerebellar granule neuron precursors.
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Cites
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Prediction of central nervous system embryonal tumour outcome based on gene expression
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Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
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c-Myc Target Genes Involved in Cell Growth, Apoptosis, and Metabolism
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Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
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Cited by
Hedgehog: functions and mechanisms
Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217
Neural Stem Cells and the Origin of Gliomas
Sanai, N., Alvarez-Buylla, A., & Berger, M. S. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043666 · Cited by 1,044
Hedgehog signalling in cancer formation and maintenance
di Magliano, M. P., & Hebrok, M. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1229 · Cited by 829
Valk-Lingbeek, M. E., Bruggeman, S. W. M., & van Lohuizen, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.005 · Cited by 743
Yang, Z.-J., Ellis, T., Markant, S. L., Read, T.-A., Kessler, J. D., Bourboulas, M., Schüller, U., Machold, R., Fishell, G., Rowitch, D. H., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.07.003 · Cited by 698
Self-citation
Metadata
- Authors
- Kenney, A. M., Cole, M. D., & Rowitch, D. H.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-01-01
- Volume
- 130
- Issue
- 1
- Pages
- 15-28
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2141078839
- Cited by
- 477
- References
- 88
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
