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Root or crown: a developmental choice orchestrated by the differential regulation of the epithelial stem cell niche in the tooth of two rodent species
Open accessAbstract
The rodent incisor grows continuously throughout its lifetime. The epithelial stem cell niche is located at the apical end of the tooth and its progeny gives rise to the ameloblasts that form the hard enamel. Previously,mesenchymal FGF10 was shown to support the niche, in conjunction with epithelial Notch signaling. Here we show that in a different continuously growing tooth type, the molar of the sibling vole, a similar regulatory system is in place. Moreover, the identical expression pattern of Bmp4compared to Fgf10 suggests that BMP4 could also be involved in the regulation of the epithelial stem cell niche. Notch and FGF10 signaling is mainly absent in the mouse molar, which stops growing and develops roots. The regulation of the epithelial stem cell niche seems to be flexible allowing for the existence of different tooth types, such as continuously growing teeth,and high and low crowned molars.
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Citations
Cited by
Molecular and cellular mechanisms of tooth development, homeostasis and repair
Yu, T., & Klein, O. D. (2020) · Development · doi:10.1242/dev.184754 · Cited by 267
Cellular and molecular mechanisms of tooth root development
Li, J., Parada, C., & Chai, Y. (2017) · Development · doi:10.1242/dev.137216 · Cited by 265
An ancient gene network is co-opted for teeth on old and new jaws
Fraser, G. J., Hulsey, C. D., Bloomquist, R. F., Uyesugi, K., Manley, N. R., & Streelman, J. T. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000031 · Cited by 228
Metadata
- Authors
- Tummers, M., & Thesleff, I.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-03-15
- Volume
- 130
- Issue
- 6
- Pages
- 1049-1057
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1968021351
- Cited by
- 213
- References
- 0
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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