Xenopus Cyr61 regulates gastrulation movements and modulates Wnt signalling
Abstract
Cyr61 is a secreted, heparin-binding, extracellular matrix-associated protein whose activities include the promotion of adhesion and chemotaxis, and the stimulation of fibroblast and endothelial cell growth. Many, if not all,of these activities of Cyr61 are mediated through interactions with integrins. We explore the role of Cyr61 in the early development of Xenopus laevis. Gain- and loss-of-function experiments show that Xcyr61 is required for normal gastrulation movements. This role is mediated in part through the adhesive properties of Xcyr61 and its related ability to modulate assembly of the extracellular matrix. In addition, Xcyr61 can, in a context-dependent manner, stimulate or inhibit signalling through the Wnt pathway. These properties of Xcyr61 provide a mechanism for integrating cell signalling, cell adhesion and cell migration during gastrulation.
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In Xenopus laevis, gain- and loss-of-function experiments have shown that precise control of CCN1 expression is required for normal gastrulation movements and modulation of Wnt signaling.
“In Xenopus laevis, gain- and loss-of-function experiments have shown that precise control of CCN1 expression is required for normal gastrulation movements and modulation of Wnt signaling [99].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [99]
Ventral injection of Ccn1 mRNA induces secondary axis formation in Xenopus and activates Wnt/β-catenin signaling, but can also inhibit Wnt8-induced secondary axis formation, indicating that CCN1 can stimulate or inhibit Wnt signaling in a context-dependent manner.
“Ventral injection of Ccn1 mRNA induces secondary axes formation in Xenopus and activates Wnt/β-catenin signaling, but can also inhibit Wnt8-induced secondary axis formation, indicating that CCN1 can stimulate or inhibit Wnt signaling in a context-dependent manner [99].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [99]
Either overexpression of CCN1 by injection of Ccn1 RNA or CCN1 knockdown by antisense morpholino oligonucleotides caused defects in gastrulation, resulting in severe delay of blastopore closure.
“Either overexpression of CCN1 by injection of Ccn1 RNA or CCN1 knockdown by antisense morpholino oligonucleotides caused defects in gastrulation, resulting in severe delay of blastopore closure.”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [99]
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References 78 · Cited by 77
- Authors
- Latinkic, B. V., Mercurio, S., Bennett, B., Hirst, E. M. A., Xu, Q., Lau, L. F., Mohun, T. J., & Smith, J. C.
- Affiliations
- National Institute for Medical Research (GB)
- University of Cambridge (GB)
- University of Illinois Chicago (US)
- Corresponding author
- Smith, J. C.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-06-01
- Volume
- 130
- Issue
- 11
- Pages
- 2429-2441
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2161481085
- Cited by
- 77
- References
- 78
- Citations by year
- 2026: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 1 · 2012: 4
- FWCI
- 3.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- BOA (University of Milano-Bicocca) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- CYR61, gastrulation, Wnt signaling, extracellular matrix, cell adhesion, cell migration, integrin signaling, Xenopus laevis, early embryonic development, gain and loss of function
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cell Adhesion, Cell Movement, Cytoskeletal Proteins, Gastrula, Molecular Sequence Data, Proto-Oncogene Proteins, Xenopus laevis, Signal Transduction, Trans-Activators, Sequence Homology, Amino Acid, Immediate-Early Proteins, DNA, Complementary, Gene Expression Regulation, Developmental, Bone Morphogenetic Proteins, Heparan Sulfate Proteoglycans, Oligodeoxyribonucleotides, Antisense, Xenopus Proteins, Zebrafish Proteins, Intercellular Signaling Peptides and Proteins, Wnt Proteins, beta Catenin, Cysteine-Rich Protein 61
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