The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Pitx3 is required for motor activity and for survival of a subset of midbrain dopaminergic neurons
Abstract
Mesencephalic dopaminergic (MesDA) neurons play crucial roles in motor and behavioral processes; their loss in Parkinson's disease (PD) results in striatal dopamine (DA) deficiency and hypokinetic movement disorder. The Pitx3 homeobox gene is expressed in the MesDA system. We now show that only a subset of MesDA neurons express Pitx3 and that in Pitx3-deficient aphakia mice, this subset is progressively lost by apoptosis during fetal (substantia nigra, SN) and postnatal (ventral tegmental area) development, resulting in very low striatal DA and akinesia. Similar to human PD, dorsal SN neurons (which are Pitx3 negative) are spared in mutant mice. Thus, Pitx3 defines a pathway for survival of neurons that are implicated in PD and that are required for spontaneous locomotor activity.
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Cites
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
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Cited by
A MicroRNA Feedback Circuit in Midbrain Dopamine Neurons
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The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease
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Dopamine-dependent motor learning: insight into levodopa's long-duration response
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Metadata
- Authors
- van den Munckhof, P., Luk, K. C., Ste-Marie, L., Montgomery, J., Blanchet, P. J., Sadikot, A. F., & Drouin, J.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2003-06-01
- Volume
- 130
- Issue
- 11
- Pages
- 2535-2542
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2107947404
- Cited by
- 299
- References
- 5
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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