The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme
Open accessAbstract
The effects of Wnt7b on lung development were examined using a conditional Wnt7b-null mouse. Wnt7b-null lungs are markedly hypoplastic,yet display largely normal patterning and cell differentiation. In contrast to findings in prior hypomorphic Wnt7b models, we find decreased replication of both developing epithelium and mesenchyme, without abnormalities of vascular smooth muscle development. We further demonstrate that Wnt7b signals to neighboring cells to activate both autocrine and paracrine canonical Wnt signaling cascades. In contrast to results from hypomorphic models, we show that Wnt7b modulates several important signaling pathways in the lung. Together, these cascades result in the coordinated proliferation of adjacent epithelial and mesenchymal cells to stimulate organ growth with few alterations in differentiation and patterning.
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Bitgood, M. J., & McMahon, A. P. (1995) · Developmental Biology · doi:10.1006/dbio.1995.0010 · Cited by 1,370
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Cited by
Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development
Morrisey, E. E., & Hogan, B. L. M. (2010) · Developmental Cell · doi:10.1016/j.devcel.2009.12.010 · Cited by 964
The Id2+ distal tip lung epithelium contains individual multipotent embryonic progenitor cells
Rawlins, E. L., Clark, C. P., Xue, Y., & Hogan, B. L. M. (2009) · Development · doi:10.1242/dev.037317 · Cited by 371
Lüdtke, T. H., Rudat, C., Wojahn, I., Weiss, A.-C., Kleppa, M.-J., Kurz, J., Farin, H. F., Moon, A., Christoffels, V. M., & Kispert, A. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.08.007 · Cited by 69
Metadata
- Authors
- Rajagopal, J., Carroll, T. J., Guseh, J. S., Bores, S. A., Blank, L. J., Anderson, W. J., Yu, J., Zhou, Q., McMahon, A. P., & Melton, D. A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2008-05-01
- Volume
- 135
- Issue
- 9
- Pages
- 1625-1634
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2123356579
- Cited by
- 161
- References
- 1
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Rajagopal, J., Carroll, T. J., Guseh, J. S., Bores, S. A., Blank, L. J., Anderson, W. J., Yu, J., Zhou, Q., McMahon, A. P., & Melton, D. A. (2008). Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development. https://doi.org/10.1242/dev.015495
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
