The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Distinct and sequential tissue-specific activities of the LIM-class homeobox gene Lim1 for tubular morphogenesis during kidney development
Open accessAbstract
Kidney organogenesis requires the morphogenesis of epithelial tubules. Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mesenchyme-to-epithelium transitions and tubular morphogenesis to form nephrons, the functional units of the kidney. The LIM-class homeobox gene Lim1 is expressed in the intermediate mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivatives. Lim1-null mice lack kidneys because of a failure of nephric duct formation, precluding studies of the role of Lim1 at later stages of kidney development. Here, we show that Lim1 functions in distinct tissue compartments of the developing metanephros for both proper development of the ureteric buds and the patterning of renal vesicles for nephron formation. These observations suggest that Lim1 has essential roles in multiple steps of epithelial tubular morphogenesis during kidney organogenesis. We also demonstrate that the nephric duct is essential for the elongation and maintenance of the adjacent Müllerian duct, the anlage of the female reproductive tract.
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Citations
Cites
Requirement for LIml in head-organizer function
Shawlot, W., & Behringer, R. R. (1995) · Nature · doi:10.1038/374425a0 · Cited by 805
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Cited by
Cessation of renal morphogenesis in mice
Hartman, H. A., Lai, H. L., & Patterson, L. T. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.08.021 · Cited by 305
Metadata
- Authors
- Kobayashi, A., Kwan, K.-M., Carroll, T. J., McMahon, A. P., Mendelsohn, C. L., & Behringer, R. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-06-15
- Volume
- 132
- Issue
- 12
- Pages
- 2809-2823
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2083356835
- Cited by
- 357
- References
- 1
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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