The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development
Abstract
Defects in cardiac valve morphogenesis and septation of the heart chambers constitute some of the most common human congenital abnormalities. Some of these defects originate from errors in atrioventricular (AV) endocardial cushion development. Although this process is being extensively studied in mouse and chick, the zebrafish system presents several advantages over these models, including the ability to carry out forward genetic screens and study vertebrate gene function at the single cell level. In this paper, we analyze the cellular and subcellular architecture of the zebrafish heart during stages of AV cushion and valve development and gain an unprecedented level of resolution into this process. We find that endocardial cells in the AV canal differentiate morphologically before the onset of epithelial to mesenchymal transformation, thereby defining a previously unappreciated step during AV valve formation. We use a combination of novel transgenic lines and fluorescent immunohistochemistry to analyze further the role of various genetic (Notch and Calcineurin signaling) and epigenetic (heart function)pathways in this process. In addition, from a large-scale forward genetic screen we identified 55 mutants, defining 48 different genes, that exhibit defects in discrete stages of AV cushion development. This collection of mutants provides a unique set of tools to further our understanding of the genetic basis of cell behavior and differentiation during AV valve development.
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Cites
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“-Secretase is required for the activation of the Notch signaling pathway (reviewed by Mumm and Kopan, 2000) and DAPT-treated zebrafish embryos have somitogenesis and neurogenesis phenotypes identical to those caused by a loss of Notch signaling (Geling et al., 2002).”
BackgroundSelf-citationStructural development of endocardial cushions
Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977) · American Journal of Anatomy · doi:10.1002/aja.1001480108 · Cited by 489
A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis
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Cited by
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,025
Self-citationDeep and fast live imaging with two-photon scanned light-sheet microscopy
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Heart Valve Development: Regulatory Networks in Development and Disease
Combs, M. D., & Yutzey, K. E. (2009) · Circulation Research · doi:10.1161/circresaha.109.201566 · Cited by 455
Sabine, A., Agalarov, Y., Maby-El Hajjami, H., Jaquet, M., Hägerling, R., Pollmann, C., Bebber, D., Pfenniger, A., Miura, N., Dormond, O., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.12.020 · Cited by 411
Proinflammatory Signaling Regulates Hematopoietic Stem Cell Emergence
Espín-Palazón, R., Stachura, D. L., Campbell, C. A., García-Moreno, D., Del Cid, N., Kim, A. D., Candel, S., Meseguer, J., Mulero, V., & Traver, D. (2014) · Cell · doi:10.1016/j.cell.2014.10.031 · Cited by 333
Metadata
- Authors
- Beis, D., Bartman, T., Jin, S.-W., Scott, I. C., D'Amico, L. A., Ober, E. A., Verkade, H., Frantsve, J., Field, H. A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J.-N., Stainier, D. Y. R., & Jungblut, B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2005-09-15
- Volume
- 132
- Issue
- 18
- Pages
- 4193-4204
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2101816987
- Cited by
- 359
- References
- 4
- FWCI
- 4.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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