The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The origin and identity of embryonic stem cells
Abstract
Embryonic stem (ES) cells are used extensively in biomedical research and as a model with which to study early mammalian development, but their exact origin has been subject to much debate. They are routinely derived from pre-implantation embryos, but it has been suggested that the cells that give rise to ES cells might arise from epiblast cells that are already predisposed to a primordial germ cell (PGC) fate, which then progress to ES cell status via the PGC lineage. Based on recent findings, we propose here that ES cells can be derived directly from early epiblast cells and that ES cells might arise via two different routes that are dictated by their culture conditions.
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Citations
Cites
The ground state of embryonic stem cell self-renewal
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L., Doble, B., Woodgett, J., Cohen, P., & Smith, A. (2008) · Nature · doi:10.1038/nature06968 · Cited by 3,442
Self-citationChazaud, C., Yamanaka, Y., Pawson, T., & Rossant, J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.02.020 · Cited by 898
Strain difference in establishment of mouse embryonic stem (ES) cell lines
Kawase, E., Suemori, H., Takahashi, N., Okazaki, K., Hashimoto, K., & Nakatsuji, N. (1994) · The International Journal of Developmental Biology · doi:10.1387/ijdb.7981049 · Cited by 203
Reflections on the biology of embryonic stem (ES) cells
Gardner, R. L., & Brook, F. A. (1997) · The International Journal of Developmental Biology · doi:10.1387/ijdb.9184330 · Cited by 123
Cited by
Boroviak, T., Loos, R., Bertone, P., Smith, A., & Nichols, J. (2014) · Nature Cell Biology · doi:10.1038/ncb2965 · Cited by 441
Self-citationComparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models
Bahl, V., Lin, S., Xu, N., Davis, B., Wang, Y.-H., & Talbot, P. (2012) · Reproductive Toxicology · doi:10.1016/j.reprotox.2012.08.001 · Cited by 375
Maintaining embryonic stem cell pluripotency with Wnt signaling
Sokol, S. Y. (2011) · Development · doi:10.1242/dev.066209 · Cited by 257
Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation
Chen, G., Schell, J. P., Benitez, J. A., Petropoulos, S., Yilmaz, M., Reinius, B., Alekseenko, Z., Shi, L., Hedlund, E., Lanner, F., et al. (2016) · Genome Research · doi:10.1101/gr.201954.115 · Cited by 123
Metadata
- Authors
- Nichols, J., & Smith, A.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2011-01-01
- Volume
- 138
- Issue
- 1
- Pages
- 3-8
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W2063052421
- Cited by
- 210
- References
- 4
- FWCI
- 7.56
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
